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| Status |
Public on Oct 22, 2012 |
| Title |
Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer [RPPA-Longterm] |
| Organism |
Homo sapiens |
| Experiment type |
Protein profiling by protein array
|
| Summary |
EGFR-inhibition is required for targeted therapies of EGFR high/ERBB2 positive breast cancer.
Approximately 30% of human ERBB2 positive breast tumors also express EGFR.
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| Overall design |
Three therapeutics were analyzed in five combinations plus control. Each experiment was performed in three biological replicates. This resulted in 180 samples. Exceptionally, time point 18 has just two biological replicates, and time point 48 just one. A dilution series of control lysated was included as control.
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| Contributor(s) |
Henjes F, Bender C, von der Heyde S, Braun L, Mannsperger HA, Schmidt C, Wiemann S, Hasmann M, Aulmann S, Beissbarth T, Korf U |
| Citation(s) |
23552733, 24970389 |
| |
| Submission date |
Mar 07, 2012 |
| Last update date |
Aug 13, 2014 |
| Contact name |
Ulrike Korf |
| E-mail(s) |
u.korf@dkfz.de
|
| Phone |
0049 (0) 6221 424765
|
| Fax |
0049 (0) 6221 423454
|
| Organization name |
German Cancer Research Center
|
| Department |
Molecular Genome Analysis
|
| Street address |
Im Neuenheimer Feld 580
|
| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (1) |
| GPL15318 |
Targeted array-based proteomics [RPPA-Longterm] |
|
| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE36327 |
Targeted inhibition of human breast cancer cell lines selected as model systems of ERBB2-positive/EGFR high breast cancer |
| GSE50109 |
Targeted inhibition of three human breast cancer cell lines as model systems of ERBB2-positive breast cancer |
|
| Relations |
| BioProject |
PRJNA155573 |
