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Series GSE35366 Query DataSets for GSE35366
Status Public on Jan 26, 2012
Title Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects
Organism Mus musculus
Experiment type Expression profiling by array
Summary Proper cortical development relies on the balance of neuronal migration and proliferation. We investigated the gene expression differences of mouse knock-outs for Lissencephaly in humans.
Our analysis suggests that gene expression and pathway analysis in mouse models of a similar disorder or within a common pathway can be used to define novel candidates for related human diseases.
 
Overall design We investigated the developing brain of four mutants and wild-type mice using expression microarrays, bioinformatic analyses, and in vivo/in vitro experiments to address whether mutations in different members of the LIS1 neuronal migration complex lead to similar and/or distinct global gene expression alterations.
 
Contributor(s) Pramparo T, Wynsha-Boris A
Citation(s) 21423666
Submission date Jan 26, 2012
Last update date Feb 11, 2019
Contact name Tiziano Pramparo
Organization name UCSD
Department Neurosciences
Lab Courchesne
Street address 8110 La Jolla Shores Drive
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (78)
GSM866834 E14 - WTMixB 1
GSM866835 E14 - WTMixB 2
GSM866836 E14 - WTMixB 3
Relations
BioProject PRJNA152639

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE35366_RAW.tar 282.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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