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Series GSE35160 Query DataSets for GSE35160
Status Public on Feb 01, 2012
Title Functional analysis of the cytoprotective transcription factor Nrf2 in skin morphogenesis and disease: Identification of Nrf2 target genes
Organism Mus musculus
Experiment type Expression profiling by array
Summary The Nrf2 transcription factor is a key player in the cellular stress response, which regulates the expression of important antioxidant enzymes and other cytoprotective proteins. We recently generated a novel transgenic mouse model to determine the function of Nrf2 in the skin. These mice revealed interesting phenotypic abnormalities, including hyperkeratosis and acanthosis. To gain insight into the underlying molecular mechanisms, we wanted to identify genes, which are differentially expressed in the skin of wild-type and mutant mice before the onset of phenotypic abnormalities.
Overall design RNA from whole skin of 3 single P2.5 K5cre-caNrf2 (tg/tg) and 3 single P2.5 K5cre-wt (tg/wt=control) mice were used
Contributor(s) Schäfer M, Werner S, Zoller S, Aquino C, Rehrauer H
Citation(s) 22383093
Submission date Jan 17, 2012
Last update date Feb 11, 2019
Contact name Matthias Schäfer
Phone +41-44-633 3406
Fax +41-44-633 1174
Organization name ETH Zürich
Department Department of Cell Biology
Lab Werner
Street address Schafmattstrasse 18
City Zürich
State/province ZH
ZIP/Postal code 8093
Country Switzerland
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM862835 transgene strong 1
GSM862836 transgene strong 2
GSM862837 transgene strong 3
BioProject PRJNA150787

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Supplementary file Size Download File type/resource
GSE35160_RAW.tar 21.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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