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Series GSE35108 Query DataSets for GSE35108
Status Public on Feb 01, 2012
Title Expression data from patient iPSC and iPSC-derived cardiomyocytes
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Dilated cardiomyopathy (DCM) is the leading cause of heart failure and transplantation worldwide. We used iPSCs to model this disease and compared gene expression change before and after gene therapy of cardiomyocytes derived from DCM-specific iPSCs.
We used microarrays to detail the global gene expression of patient specific iPSCs, iPSC-derived cardiomyocytes and its response to gene therapy.
 
Overall design Skin fibroblasts and iPSCs derived from a family exhibiting familial dilated cardiomyopathy and H7 human ESCs were subjected to RNA extraction and hybridization on Affymetrix microarrays.Global gene expression pattern were compared and analyzed.
Cardiomyocytes derived from iPSCs generated from this DCM family were treated with or without adenoriral Serca2a and subjected to RNA extraction and hybridization on Affymetrix microarrays. Global gene expression pattern were compared and analyzed.
 
Contributor(s) Sun N, Wu JC, Han L
Citation(s) 22517884
Submission date Jan 14, 2012
Last update date Jul 26, 2018
Contact name Leng Han
E-mail(s) hanleng0926@hotmail.com
Organization name Stanford University
Street address 265 Campus Dr
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
 
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (17)
GSM862161 Skin Fibroblast
GSM862162 human embyonic stem cells (H7)
GSM862163 Induced pluripotent cells_patient Ia
Relations
BioProject PRJNA150901

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE35108_RAW.tar 76.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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