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GEO help: Mouse over screen elements for information. |
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Status |
Public on Apr 18, 2014 |
Title |
Gene expression changes in oncogenic Kras-containing, Apc-mutated mouse intestinal organoids in the presence or absence of TGF-beta |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
We isolated and selected intestinal adenoma organoids from Apc1638N/+ and Apc1638N/+; Kras mice. After the selection procedure, we maintained the cultures with or without TGF-beta for 18h. RNA was isolated to determine the effect of oncogenic Kras on the gene expression changes.
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Overall design |
Total RNA obtained from Apc1638N/+; Kras organoids were compared to Apc1638N/+ samples in the absence or presence of 3 ng/ml TGF-beta (18h).
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Contributor(s) |
Wiener Z, Hyvonen V, Alitalo K |
Citation(s) |
24825889 |
Submission date |
Jan 13, 2012 |
Last update date |
Jan 16, 2019 |
Contact name |
Zoltan Wiener |
E-mail(s) |
zoltan.wiener@helsinki.fi
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Organization name |
University of Helsinki
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Department |
Molecular Cancer Biology Programme
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Street address |
Haartmaninkatu 8
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City |
Helsinki |
ZIP/Postal code |
FI-00017 |
Country |
Finland |
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Platforms (1) |
GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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Samples (18)
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GSM861875 |
Apc-mutated organoid, untreated 1 |
GSM861876 |
Apc; Kras mutated organoid, untreated 1 |
GSM861877 |
Apc; Kras mutated organoid, untreated 2 |
GSM861878 |
Apc; Kras mutated organoid, untreated 3 |
GSM861879 |
Apc-mutated organoid, untreated 2 |
GSM861880 |
Apc-mutated organoid, untreated 3 |
GSM861881 |
Apc-mutated organoid, untreated 4 |
GSM861882 |
Apc; Kras mutated organoid, untreated 4 |
GSM861883 |
Apc; Kras mutated organoid, untreated 5 |
GSM861884 |
Apc-mutated organoid, untreated 5 |
GSM861885 |
Apc-mutated organoid, TGF-beta treated 1 |
GSM861886 |
Apc; Kras mutated organoid, TGF-beta treated 1 |
GSM861887 |
Apc-mutated organoid, TGF-beta treated 2 |
GSM861888 |
Apc; Kras mutated organoid, TGF-beta treated 2 |
GSM861889 |
Apc; Kras mutated organoid, TGF-beta treated 3 |
GSM861890 |
Apc; Kras mutated organoid, TGF-beta treated 4 |
GSM861891 |
Apc-mutated organoid, TGF-beta treated 3 |
GSM861892 |
Apc-mutated organoid, TGF-beta treated 4 |
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This SubSeries is part of SuperSeries: |
GSE35094 |
Apc, Kras, and TGFbeta in intestinal organoids |
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Relations |
BioProject |
PRJNA156157 |
Supplementary file |
Size |
Download |
File type/resource |
GSE35092_RAW.tar |
15.8 Mb |
(http)(custom) |
TAR |
GSE35092_non-normalized.txt.gz |
3.3 Mb |
(ftp)(http) |
TXT |
Processed data included within Sample table |
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