|
| Status |
Public on Feb 22, 2012 |
| Title |
Expression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We evaluated gene expression changes in secondary recipient murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of a homozygous conditional allele for Ezh2, a component of the Polycomb Repressive Complex2.
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| |
|
| Overall design |
For WT cells, 4 biological replicates were hybridized. For Ezh2-null cells, 5 biological replicates were hybridized.
|
| |
|
| Contributor(s) |
Neff T, Sinha AU, Armstrong SA |
| Citation(s) |
22396593 |
| |
| Submission date |
Jan 09, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Amit Sinha |
| E-mail(s) |
amit.sinha@childrens.harvard.edu
|
| Phone |
617-582-7579
|
| Organization name |
Dana-Farber Cancer Institute
|
| Department |
Pediatric Oncology
|
| Lab |
Armstrong Lab
|
| Street address |
44 Binney St
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02135 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (9)
|
| GSM859583 |
WT 2'MLL-AF9 BM-Cells, biological rep1 |
| GSM859584 |
WT 2'MLL-AF9 BM-Cells, biological rep2 |
| GSM859585 |
WT 2'MLL-AF9 BM-Cells, biological rep3 |
| GSM859586 |
WT 2'MLL-AF9 BM-Cells, biological rep4 |
| GSM859587 |
Ezh2-null 2'MLL-AF9 BM-Cells, biological rep1 |
| GSM859588 |
Ezh2-null 2'MLL-AF9 BM-Cells, biological rep2 |
| GSM859589 |
Ezh2-null 2'MLL-AF9 BM-Cells, biological rep3 |
| GSM859590 |
Ezh2-null 2'MLL-AF9 BM-Cells, biological rep4 |
| GSM859591 |
Ezh2-null 2'MLL-AF9 BM-Cells, biological rep5 |
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| This SubSeries is part of SuperSeries: |
| GSE34963 |
The Polycomb Repressive Complex 2 Is Required For MLL-AF9 Leukemia |
|
| Relations |
| BioProject |
PRJNA156137 |
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