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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 13, 2011 |
| Title |
Mouse peritoneal macrophages at 3.5 or 48 hours, 0,0.5 or 5 μg/ml Leukocyte cell-derived chemotaxin 2 (LECT2),gene expression array, two independent biological replicates |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
LECT2 is a liver derived cytokine and involved in many pathologic conditions, especially in immune regulation. To better understand cellular and molecular mechanisms of LECT2 in immune response, mouse peritoneal macrophages were isolated from mouse peritonaeum. After treatment with 0, 0.5 or 5 μg/ml of LECT2 for 3.5 or 48 hours, gene expression profile in mouse peritoneal macrophages was measured using gene expression array. Results showed that LECT2 treatment led to the enhancement of cytokines secretion and phagocytosis in peritoneal macrophages.
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| Overall design |
Gene expression in mouse peritoneal macrophages isolated from mouse peritonaeum were measured after exposure to 0,0.5 or 5 μg/ml LECT2 for 3.5 or 48 hours using gene expression array. Two independent experiments were performed using different mice for each experiment for gene expression array analysis.
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| Contributor(s) |
Chen J, Lu X, Shi Y, Zhang R, Lv J, Huang Z |
| Citation(s) |
23254286 |
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| Submission date |
Nov 15, 2011 |
| Last update date |
Nov 01, 2017 |
| Contact name |
wang liang |
| E-mail(s) |
wangliangkexue@163.com
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| Organization name |
BioChainBJ
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| Street address |
7A North Yongchang Road BDA
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| City |
Beijing |
| ZIP/Postal code |
100176 |
| Country |
China |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (8)
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| GSM833350 |
Low dosage of LECT2 vs control, 3.5 hours, biological replicate 1 of 2 |
| GSM833351 |
High dosage of LECT2 vs control, 3.5 hours, biological replicate 1 of 2 |
| GSM833352 |
Low dosage of LECT2 vs control, 48 hours, biological replicate 1 of 2 |
| GSM833353 |
High dosage of LECT2 vs control, 48 hours, biological replicate 1 of 2 |
| GSM833354 |
Low dosage of LECT2 vs control, 3.5 hours, biological replicate 2 of 2 |
| GSM833355 |
High dosage of LECT2 vs control, 3.5 hours, biological replicate 2 of 2 |
| GSM833356 |
Low dosage of LECT2 vs control, 48 hours, biological replicate 2 of 2 |
| GSM833357 |
High dosage of LECT2 vs control, 48 hours, biological replicate 2 of 2 |
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| Relations |
| BioProject |
PRJNA148451 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE33721_RAW.tar |
34.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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