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Series GSE33199 Query DataSets for GSE33199
Status Public on Feb 29, 2012
Title A mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Mouse models of medulloblastoma are compared to human subgroups through microarray expression and other measures
 
Overall design This study contrasts mouse medullablastomas from a range of mouse genetic models. For Shh-type medulloblastoma [dka001-005, 009, 033 and 034] and [dka050-057], spontaneous medulloblastomas from [Cdkn2c-/-; Trp53Fl/Fl; Nestin-Cre] and [Cdkn2c-/-; Ptch1+/-] (Uziel et al.,2005 Genes Dev) were used, respectively. For Myc [dka010-022, 037, 046, 049 and 058-71] and Mycn [dka023-032, 036 and 047] were generated by orthotopic injection of either Myc or Mycn overexpression in Cdkn2c-/-, Trp53-/- cerebellar cells into immunocompromised nude mice. For Wnt-type medulloblastomas [pgr003, 016 and 066], spontaneously developed tumors from CTNNB1+/lox (ex3); BLBP-Cre; Trp53Fl/Fl (Gibson et al., Nature, 2010) were removed for RNA extraction.
 
Contributor(s) Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF
Citation(s) 22340591
Submission date Oct 25, 2011
Last update date Feb 11, 2019
Contact name David Finkelstein
E-mail david.finkelstein@stjude.org
Phone 9014953931
Organization name St Jude Children's Research Hospital
Department Computational Biology
Street address 332 N. Lauderdale St.
City Memphis
State/province TN
ZIP/Postal code 38105
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (64)
GSM821907 dka001
GSM821908 dka002
GSM821909 dka003
This SubSeries is part of SuperSeries:
GSE33201 A mouse model of the most aggressive subgroup of human medulloblastoma
Relations
BioProject PRJNA156633

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33199_RAW.tar 228.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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