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Series GSE33101 Query DataSets for GSE33101
Status Public on Dec 01, 2011
Title Gene expression profiles in Sirt1/PPARalpha bigenic mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Cardiac-specific PPARalpha transgenic (Tg-PPARalpha) mice show mild cardiac hypertrophy and systolic dysfunction. The failing heart phenotypes observed in Tg-PPARalpha are exacerbated by crossing with cardiac-specific Sirt1 transgenic (Tg-Sirt1) mice, whereas Tg-Sirt1 mice themselves do not show any cardiac hypertrophy or systolic dysfunction. To investigate the mechanism leading to the failing heart phenotypes in TgPPARalpha/Tg-Sirt1 bigenic mice, microarray analyses were performed. The microarray analyses revealed that many ERR target genes were downregulated in Tg-PPARalpha and in Tg-Sirt1, and they were further downregulated in the Tg-PPARalpha/Tg-Sirt1 bigenic mice.
Overall design Four groups of cardiac-specific transgenic mice were used for the study, i.e., control, PPARalpha, Sirt1 and PPARalpha/Sirt1. Hearts were dissected after 10-11 weeks of male FVB background transgenic mice. Total RNA was prepared from the hearts to conduct the microarray analyses.
Contributor(s) Shinichi O, Park JY, Tian B, Sadoshima J
Citation(s) 22055503, 26241474
Submission date Oct 19, 2011
Last update date Apr 07, 2020
Contact name Jiyeon Park
Organization name Seoul National Univerisy
Department Biomedical Informatics
Lab Bioinformatics
Street address 103 Daehak-ro, Jongno-gu
City Seoul
ZIP/Postal code 110-799
Country South Korea
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (8)
GSM819797 WT rep1
GSM819798 WT rep2
GSM819799 Tg-Sirt1 rep1
BioProject PRJNA149333

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33101_RAW.tar 30.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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