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| Status |
Public on Mar 16, 2012 |
| Title |
Autoantibody profile timecourse of UNK |
| Organism |
Homo sapiens |
| Experiment type |
Protein profiling by protein array
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| Summary |
We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyomes from blood components have revealed extensive, dynamic and broad changes in diverse molecular components and biological pathways that occurred during healthy and disease states. Many changes were associated with allele- and edit-specific expression at the RNA and protein levels, which may contribute to personalized responses. Importantly, genomic information was also used to predict medical risks, including Type II Diabetes (T2D), whose onset was observed during the course of our study using standard clinical tests and molecular profiles, and whose disease progression was monitored and subsequently partially managed. Our study demonstrates that longitudinal personal omics profiling can relate genomic information to global functional omics activity for physiological and medical interpretation of healthy and disease states.
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| Overall design |
Plasma and serum from a virus infected timepoint (in triplicate) and 34 healthy contorl samples were collected and used to probe Invitrogen human protoarray v5.0.
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| Contributor(s) |
Chen R, Mias GI, Li-Pook-Than J, Lam H, Jiang L, Chen R, Miriami E, Karczewski K, Hariharan M, Dewey F, Lin S, Habegger L, Clark MJ, Balasubramanian S, Cheng Y, O'Huallachain M, Dudley J, Hillemenyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Seki S, Garcia M, Im H, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte A, Ashley E, Nadeau K, Gerstein M, Tang H, Snyder M |
| Citation(s) |
22424236 |
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| Submission date |
Oct 07, 2011 |
| Last update date |
Mar 23, 2012 |
| Contact name |
Hogune Im |
| Phone |
650-723-3277
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| Organization name |
Stanford
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| Department |
Genetics
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| Lab |
Snyder
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| Street address |
300 Pasteur Dr. Alway M308
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (1) |
| GPL14689 |
Invitrogen ProtoArray v5.0 (full array layout) |
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| Samples (37)
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| GSM812337 |
Autoantibody profiling of normal sample 1 |
| GSM812338 |
Autoantibody profiling of normal sample 2 |
| GSM812339 |
Autoantibody profiling of normal sample 3 |
| GSM812340 |
Autoantibody profiling of normal sample 4 |
| GSM812341 |
Autoantibody profiling of normal sample 5 |
| GSM812342 |
Autoantibody profiling of normal sample 6 |
| GSM812343 |
Autoantibody profiling of normal sample 7 |
| GSM812344 |
Autoantibody profiling of normal sample 8 |
| GSM812345 |
Autoantibody profiling of normal sample 9 |
| GSM812346 |
Autoantibody profiling of normal sample 10 |
| GSM812347 |
Autoantibody profiling of normal sample 11 |
| GSM812348 |
Autoantibody profiling of normal sample 12 |
| GSM812349 |
Autoantibody profiling of normal sample 13 |
| GSM812350 |
Autoantibody profiling of normal sample 14 |
| GSM812351 |
Autoantibody profiling of normal sample 15 |
| GSM812352 |
Autoantibody profiling of normal sample 16 |
| GSM812353 |
Autoantibody profiling of normal sample 17 |
| GSM812354 |
Autoantibody profiling of normal sample 18 |
| GSM812355 |
Autoantibody profiling of normal sample 19 |
| GSM812356 |
Autoantibody profiling of normal sample 20 |
| GSM812357 |
Autoantibody profiling of normal sample 21 |
| GSM812358 |
Autoantibody profiling of normal sample 22 |
| GSM812359 |
Autoantibody profiling of normal sample 23 |
| GSM812360 |
Autoantibody profiling of normal sample 24 |
| GSM812361 |
Autoantibody profiling of normal sample 25 |
| GSM812362 |
Autoantibody profiling of normal sample 26 |
| GSM812363 |
Autoantibody profiling of normal sample 27 |
| GSM812364 |
Autoantibody profiling of normal sample 28 |
| GSM812365 |
Autoantibody profiling of normal sample 29 |
| GSM812366 |
Autoantibody profiling of normal sample 30 |
| GSM812367 |
Autoantibody profiling of normal sample 31 |
| GSM812368 |
Autoantibody profiling of normal sample 32 |
| GSM812369 |
Autoantibody profiling of normal sample 33 |
| GSM812370 |
Autoantibody profiling of normal sample 34 |
| GSM812371 |
Autoantibody profileing of test person at a disease contrated timepoint (1) |
| GSM812372 |
Autoantibody profileing of test person at a disease contrated timepoint (2) |
| GSM812373 |
Autoantibody profileing of test person at a disease contrated timepoint (3) |
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| This SubSeries is part of SuperSeries: |
| GSE33029 |
Integrated analysis of omics profiles |
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| Relations |
| BioProject |
PRJNA154369 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32691_RAW.tar |
98.2 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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