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Series GSE3143 Query DataSets for GSE3143
Status Public on Nov 07, 2005
Title Breast Cancer Dataset
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Signatures of Oncogenic Pathway Deregulation in Human Cancers.

The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. When evaluated in several large collections of human cancers, these gene expression signatures identify patterns of pathway deregulation in tumors, and clinically relevant associations with disease outcomes. Combining signature-based predictions across several pathways identifies coordinated patterns of pathway deregulation that distinguish between specific cancers and tumor sub-types. Clustering tumors based on pathway signatures further defines prognosis in respective patient subsets, demonstrating that patterns of oncogenic pathway deregulation underlie the development of the oncogenic phenotype and reflect the biology and outcome of specific cancers. Furthermore, predictions of pathway deregulation in cancer cell lines are shown to coincide with sensitivity to therapeutic agents that target components of the pathway, underscoring the potential for such pathway prediction to guide the use of targeted therapeutics.
Keywords: other
Overall design RNA was extracted from frozen tissue of primary breast tumors for gene array analysis.
Contributor(s) Nevins JR
Citation(s) 16273092
Submission date Aug 16, 2005
Last update date Dec 13, 2018
Contact name Joseph R. Nevins
Organization name Duke University
Department IGSP
Street address 2133 CIEMAS, 101 Science Dr.
City Durham
State/province NC
ZIP/Postal code 27708
Country USA
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (158)
GSM70247 T01-145
GSM70248 T01-158
GSM70249 T01-384
BioProject PRJNA92973

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