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| Status |
Public on Dec 31, 2011 |
| Title |
Expression data of MCK conditional frataxin knock-out mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Frataxin deficiency in human is the cause of Friedreich's ataxia (FA), a lethal neuro- and cardio-degenerative disease. Knock-out (KO) mice of this mouse model of FA exhibit classical cardiomyopathy of the patients. The onset of FA phenotypes in the KO mice is approximately 6-7 weeks of age. This genearray analysis was conducted to examine the changes in gene expression in the heart of KO mice relative to their wild-type (WT) littermates at 4- and 10-weeks of age. At 10-weeks of age, the KO mice begin to die from severe cardiomyopathy.
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| Overall design |
RNA from the heart of four female 4-week-old MCK littermates (two WT and two KO) and four female 10-week-old MCK littermates (two WT and two KO) was extracted and hybridised to Affymetrix Mouse Genome 430 2.0 Array.
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| |
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| Contributor(s) |
Huang ML, Richardson DR |
| Citation(s) |
19805308 |
| |
| Submission date |
Aug 04, 2011 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Michael Li-Hsuan Huang |
| Organization name |
University of Sydney
|
| Department |
Pathology
|
| Lab |
Iron Metabolism and Chelation
|
| Street address |
Level 5 Blackburn Building D06, University of Sydney
|
| City |
Sydney |
| State/province |
NSW |
| ZIP/Postal code |
2006 |
| Country |
Australia |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA145983 |
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