|
| Status |
Public on Aug 22, 2011 |
| Title |
Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA-sequencing |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Here, we apply differential transcriptome analysis on microscopically isolated cell populations, to define five transcriptional programs that represent each transient embryonic zone and the progression between these zones. The five transcriptional programs contain largely uncharacterized genes in addition to transcripts necessary for stem cell maintenance, neurogenesis, migration, and differentiation. Additionally, we found intergenic transcriptionally active regions that possibly encode novel zone-specific transcripts. Finally, we present a high-resolution transcriptome map of transient zones in the embryonic mouse forebrain.
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| |
|
| Overall design |
mRNAseq performed after laser microdissection of cells from transient embryonic zones in the mouse cortex
|
| Web link |
http://rakiclab.med.yale.edu/transcriptome.php
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| |
|
| Contributor(s) |
Ayoub AE, Oh S, Xie Y, Leng J, Cotney J, Dominguez MH, Noonan JP, Rakic P |
| Citation(s) |
21873192 |
| |
| Submission date |
Jul 18, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Albert E. Ayoub |
| Organization name |
Yale University
|
| Department |
Neurobiology
|
| Street address |
333 Cedar St. SHM C317
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06460 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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| Samples (12)
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|
| Relations |
| SRA |
SRP007510 |
| BioProject |
PRJNA144333 |
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