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Series GSE29488 Query DataSets for GSE29488
Status Public on Jan 01, 2012
Title Patterns of gene Expression during the Spinal cord Injury/Regeneration
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Spinal cord injury (SCI) induces a sequence of endogenous autodestructive changes known as secondary injury, as well as reactive biochemical changes that are neuroprotective and/or promote recovery. All these responses to SCI are, in part reflected in changes in gene expression.
In order to assess changes in gene expression involved in the regeneration process,microarrays were performed as a function of time after SCI for the various treatments.
 
Overall design Three groups rats(i.e.NT-3-chitosan tube group, tube alone group and lesion control group) used to interrogate Affymetrix (SantaClara,CA) GeneChips were sacrificed by intraperitoneally over dose injecting 6% chloral hydrate at 1, 3, 10, 20, 30, and 90 d after the operation. The spinal cords were surgically re-exposed and spinal tissue including dura and meninges was dissected into three blocks, i.e. 5 mm long segments in the lesioned area (M), rostral to the lesioned area (R), and caudal to the lesioned areas (C) were sampled under RNAase-free conditions. The samples were quick frozen and kept in liquid nitrogen.
 
Contributor(s) Li X
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date May 23, 2011
Last update date Jul 31, 2017
Contact name Li Xiaoguang
E-mail(s) lxgchina@sina.com
Phone 086101083911570
Fax 086101083911570
Organization name Beihang University
Department School of Biological Science and Medical Engineering
Lab Neural and Tissue Engineering Lab
Street address No.37 of Xueyuan Road, Haidian District
City Beijing
ZIP/Postal code 100191
Country China
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (172)
GSM729442 NT-3-chitosan tube (S), rostral to the lesion (R), 1 day post-op, biol rep1
GSM729443 NT-3-chitosan tube (S), rostral to the lesion (R), 1 day post-op, biol rep2
GSM729444 NT-3-chitosan tube (S), rostral to the lesion (R), 1 day post-op, biol rep3
Relations
BioProject PRJNA141649

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29488_RAW.tar 466.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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