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| Status |
Public on Feb 17, 2026 |
| Title |
Effect of interferon gamma on wild type and SORL1 knockout iPSC-derived microglia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This study investigates the transcriptomic response of wild-type (WT) and SORL1 knockout (KO) iPSC-derived microglia following treatment. For microglia differentiation protocol please see PMID: 38600587. Bulk RNA sequencing was performed to assess gene expression changes induced by a 48-hour treatment with 10 ng/ml of IFN-γ. The study aims to explore the role of SORL1 in microglial function and its potential impact on neuroinflammatory or neurodegenerative pathways. Differential gene expression analysis will help identify pathways regulated by SORL1 deficiency in response to external stimuli.
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| Overall design |
Bulk RNA-Seq was performed on wild-type and SORL1 knockout iPSC-derived microglia following a 48-hour treatment with 10 ng/ml IFN-γ, with appropriate untreated controls
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| Contributor(s) |
Haq I, Ngo JC, Roy N, Sher F |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 AG070118 |
Functional dissection of fibronectin type 3 domains of SORL1 in Alzheimers disease associated microglia |
Trustees of Columbia University in the City of New York |
Falak Sher |
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| Submission date |
Feb 17, 2025 |
| Last update date |
Feb 17, 2026 |
| Contact name |
Falak Sher |
| E-mail(s) |
fs2644@cumc.columbia.edu
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| Organization name |
Columbia University
|
| Street address |
630 W 168th street
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| City |
New York |
| State/province |
New York |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1224834 |
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