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Series GSE28391 Query DataSets for GSE28391
Status Public on Apr 05, 2011
Title Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis
Organisms Xenopus laevis; Gallus gallus; Mus musculus
Experiment type Expression profiling by array
Summary One of the central issues in evolutionary developmental biology is how we can formulate the relationships between evolutionary and developmental processes. Two major models have been proposed: the 'funnel-like' model, in which the earliest embryo shows the most conserved morphological pattern, followed by diversifying later stages, and the 'hourglass' model, in which constraints are imposed to conserve organogenesis stages, which is called the phylotypic period. Here we perform a quantitative comparative transcriptome analysis of several model vertebrate embryos and show that the pharyngula stage is most conserved, whereas earlier and later stages are rather divergent. These results allow us to predict approximate developmental timetables between different species, and indicate that pharyngula embryos have the most conserved gene expression profiles, which may be the source of the basic body plan of vertebrates.

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series.
Contributor(s) Irie N
Citation(s) 21427719
Submission date Apr 05, 2011
Last update date Feb 11, 2019
Contact name Naoki Irie
Organization name RIKEN Center for Developmental Biology
Lab Laboratory for Evolutionary Morphology
Street address 2-2-3 Minatojima-minami Chuo-ku
City Kobe
State/province Hyogo
ZIP/Postal code 650-0047
Country Japan
Platforms (3)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
GPL3213 [Chicken] Affymetrix Chicken Genome Array
GPL10756 [X_laevis_2] Affymetrix Xenopus laevis Genome 2.0 Array
Samples (80)
GSM701686 [E-MTAB-366] Chicken developmental stage HH1 1
GSM701687 [E-MTAB-366] Chicken developmental stage HH1 2
GSM701688 [E-MTAB-366] Chicken developmental stage HH2 1
This SuperSeries is composed of the following SubSeries:
GSE28388 [E-MTAB-366] Transcription profiling by array of chicken embryos at 15 different stages
GSE28389 [E-MTAB-368] Transcription profiling by array of mouse embryos at 8 different stages
GSE28390 [E-MTAB-369] Transcription profiling by array of Xenopus laevis embryos at 15 different stages
BioProject PRJNA139199

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28391_RAW.tar 270.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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