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Status |
Public on Mar 24, 2011 |
Title |
The androgen receptor coordinates biosynthesis and proliferation in prostate cancer |
Organism |
Homo sapiens |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
Summary |
The androgen receptor (AR) is the major therapeutic target in prostate cancer, although the important targets of the AR have remained obscure. Here we report a detailed genomic profile of AR signalling and find that the AR directly regulates glycolysis, anabolic metabolism and cell cycle regulators in prostate cancer. This coordinated transcriptional program promotes cancer cell proliferation and enhances the macromolecular synthesis needed to produce daughter cells. Clinical gene expression profiles and mechanistic studies highlight the importance of CAMKK2, an AR target which regulates both cell proliferation and metabolism. Thus our genomics study identifies a direct link between AR signalling and aerobic glycolysis (the Warburg effect), providing a new perspective on the oncogenic function of the AR in prostate cancer.
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Overall design |
8 Samples: Chromatin IP using AR and PolII in stimulated and unstimulated LNCaP and VCaP cells.
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Contributor(s) |
Charlie M, Rory S |
Citation(s) |
21602788, 21724752 |
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Submission date |
Mar 23, 2011 |
Last update date |
May 15, 2019 |
Contact name |
Suraj Menon |
E-mail(s) |
suraj.menon@cruk.cam.ac.uk
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Organization name |
Cambridge Research Institute, Cancer Research UK
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Street address |
Li Ka Shing Center, Robinson Way
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City |
Cambridge |
ZIP/Postal code |
CB2 0RE |
Country |
United Kingdom |
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Platforms (1) |
GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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Samples (8)
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Relations |
SRA |
SRP002294 |
BioProject |
PRJNA139851 |
SRA |
SRP002294 |