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Series GSE28126 Query DataSets for GSE28126
Status Public on Mar 24, 2011
Title The androgen receptor coordinates biosynthesis and proliferation in prostate cancer
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The androgen receptor (AR) is the major therapeutic target in prostate cancer, although the important targets of the AR have remained obscure. Here we report a detailed genomic profile of AR signalling and find that the AR directly regulates glycolysis, anabolic metabolism and cell cycle regulators in prostate cancer. This coordinated transcriptional program promotes cancer cell proliferation and enhances the macromolecular synthesis needed to produce daughter cells. Clinical gene expression profiles and mechanistic studies highlight the importance of CAMKK2, an AR target which regulates both cell proliferation and metabolism. Thus our genomics study identifies a direct link between AR signalling and aerobic glycolysis (the Warburg effect), providing a new perspective on the oncogenic function of the AR in prostate cancer.
 
Overall design 8 Samples: Chromatin IP using AR and PolII in stimulated and unstimulated LNCaP and VCaP cells.
 
Contributor(s) Charlie M, Rory S
Citation(s) 21602788, 21724752
Submission date Mar 23, 2011
Last update date May 15, 2019
Contact name Suraj Menon
E-mail(s) suraj.menon@cruk.cam.ac.uk
Organization name Cambridge Research Institute, Cancer Research UK
Street address Li Ka Shing Center, Robinson Way
City Cambridge
ZIP/Postal code CB2 0RE
Country United Kingdom
 
Platforms (1)
GPL9052 Illumina Genome Analyzer (Homo sapiens)
Samples (8)
GSM696839 LNCaP_AR_Vehicle
GSM696840 LNCaP_AR_AR-stimulated
GSM696841 VCaP_AR_Vehicle
Relations
SRA SRP002294
BioProject PRJNA139851
SRA SRP002294

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28126_RAW.tar 2.2 Gb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Processed data provided as supplementary file
Raw data are available in SRA

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