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Series GSE277795 Query DataSets for GSE277795
Status Public on Feb 03, 2025
Title Oncohistone H3.3K27M-driven CREB5/ID1 Axis Mediates the Malignant Cell States of Diffuse Intrinsic Pontine Glioma (DIPG) [HiC]
Organism Mus musculus
Experiment type Other
Summary Diffuse intrinsic pontine glioma (DIPG), an exceptionally lethal pediatric cancer with limited treatment options, is characterized by relentless proliferation and differentiation arrest, primarily influenced by H3K27M oncohistones. This study unveils that ID1 activation occurs independently of BMP signaling in H3.3K27M/ACVR1WT DIPG subtype. ID1 inhibition promotes cell differentiation and apoptosis in DIPG. Additionally, we discover the intricate regulation of ID1 tied to the lineage-specific transcription factor CREB5—an oncogenic contributor hindering differentiation in the H3.3K27M subtype of DIPG. The SWI/SNF complex is identified as a co-regulator of CREB5, further promoting tumorigenesis. Intriguingly, H3.3K27M oncohistones act as a trigger for CREB5 overexpression, facilitating the formation of super-enhancer promoter loops. Moreover, our research highlights the potent anti-tumor effect of ABBV-075 in treating DIPG. In essence, this study elucidates the oncohistone-driven H3.3K27M/CREB5/ID1 axis, providing insights into the malignant cellular state within a DIPG subtype and offering potential therapeutic avenues for this devastating pediatric cancer.
 
Overall design To investigate the DNA interactions impact of Creb5, the HiC-seq experiments were conducted in mouse forebrain and hindbrain NPC cells from E13.5 embryos.
 
Contributor(s) Zhou W, Xi Q
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Submission date Sep 23, 2024
Last update date Feb 04, 2025
Contact name Qiaoran Xi
E-mail(s) xiqiaoran@mail.tsinghua.edu.cn
Phone 62789636
Organization name Tsinghua University
Department School of Life Sciences
Street address Haidian District
City Beijing
ZIP/Postal code 100084
Country China
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (8)
GSM8530771 Forebrain_Hoxa9_4C-seq_rep1
GSM8530772 Forebrain_Hoxa9_4C-seq_rep2
GSM8530773 Forebrain_Hoxa13_4C-seq_rep1
This SubSeries is part of SuperSeries:
GSE250467 Oncohistone H3.3K27M-driven CREB5/ID1 Axis Mediates the Malignant Cell States of Diffuse Intrinsic Pontine Glioma (DIPG)
Relations
BioProject PRJNA1164208

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE277795_RAW.tar 710.0 Kb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA

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