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Series GSE27563 Query DataSets for GSE27563
Status Public on Mar 01, 2011
Title Expression data from murine PBCs from mice with advanced mammary tumors and their tumor-free counterparts.
Organism Mus musculus
Experiment type Expression profiling by array
Summary Female MMTV/c-MYC transgenic mice expressed the c-MYC proto-oncogene or a more stable point mutation variant (T58A) of the gene under the control of the hormone-responsive MMTV long terminal repeat (LTR) in an FVB/NJ background (Jackson Laboratories, Bar Harbor, ME). The hormones released during pregnancy and lactation have been shown to enhance expression of the oncogene. Thus, the mice were maintained in a continuous breeding program. Mice were monitored twice weekly for tumor development by palpation and tumors were measured twice weekly. Once the tumors reached 3cm3 the animals were sacrificed and tissue was obtained to confirm the tumors by histological analysis. As a control, female mice of the same age and background strain were maintained in the same facility and under the same breeding conditions as their transgenic counterparts.
 
Overall design Blood (50-250 ┬ÁL, based on weight of the mouse) was collected from MMTV/c-MYC female mice and controls at regular intervals (approximately once per month) and again prior to euthanization (average age 431 days).
 
Contributor(s) LaBreche HG, Nevins JR, Huang E
Citation(s) 21781289
Submission date Feb 28, 2011
Last update date Feb 11, 2019
Contact name Erich Huang
E-mail erich.huang@duke.edu
Phone 919-684-6849
Fax 919-681-8973
Organization name Duke University
Department Institute for Genome Sciences and Policy
Street address 101 Science Drive
City Durham
State/province NC
ZIP/Postal code 27708
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (93)
GSM682146 PBC_control_training_1
GSM682147 PBC_control_training_2
GSM682148 PBC_control_training_3
This SubSeries is part of SuperSeries:
GSE27567 Integrating Factor Analysis and a Transgenic Mouse Model to Reveal a Peripheral Blood Predictor of Breast Tumors
Relations
BioProject PRJNA141781

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27563_RAW.tar 477.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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