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| Status |
Public on Nov 11, 2024 |
| Title |
Gene expression profiling of inhibiting O-GlcNAcylation on the cellular senescence of mouse articular chondrocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
mRNA profiles of primary mouse chondrocytes treated with bleomycin, followed by DMSO or ST045849 were generated by mRNA sequencing. This study provides insights into the role of O-GlcNAcylation in chondrocytes.
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| Overall design |
To investigate the role of O-GlcNAcylation during the cellular senescence process, primary culture of mouse articular chondrocytes underwent treatment with bleomycin (50 μg/ml) for 24 h, followed by treatment with or without ST045849 (20 μM) for five days.
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| Contributor(s) |
Kim J, Kang D, Lee J |
| Citation(s) |
39904978 |
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| Submission date |
Aug 23, 2024 |
| Last update date |
Feb 12, 2025 |
| Contact name |
Jin-Hong Kim |
| E-mail(s) |
snumrl301@gmail.com
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| Organization name |
Seoul National University
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| Street address |
1 Gwanak-ro, Gwanak-gu
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| City |
Seoul |
| ZIP/Postal code |
08826 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (9)
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| GSM8478996 |
Articular chondrocytes, vehicle, rep 1 |
| GSM8478997 |
Articular chondrocytes, bleomycin plus DMSO, rep 1 |
| GSM8478998 |
Articular chondrocytes, bleomycin plus ST045849, rep 1 |
| GSM8478999 |
Articular chondrocytes, vehicle, rep 2 |
| GSM8479000 |
Articular chondrocytes, bleomycin plus DMSO, rep 2 |
| GSM8479001 |
Articular chondrocytes, bleomycin plus ST045849, rep 2 |
| GSM8479002 |
Articular chondrocytes, vehicle, rep 3 |
| GSM8479003 |
Articular chondrocytes, bleomycin plus DMSO, rep 3 |
| GSM8479004 |
Articular chondrocytes, bleomycin plus ST045849, rep 3 |
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| Relations |
| BioProject |
PRJNA1151613 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE275524_RAW.tar |
4.8 Mb |
(http)(custom) |
TAR (of TAB) |
SRA Run Selector |
| Raw data are available in SRA |
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