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| Status |
Public on Jul 28, 2024 |
| Title |
DNA Methylome Analysis of Human Cancer Cells with STELLA Protein Overexpression and the Xenograft Tumor Tissues from the Mice Treated by the Indicated LNP Formulations |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Genome-wide DNA methylation profiling of non-small cell lung cancer (NSCLC) cell line A549 and breast cancer cell line MDA-MB-231 stably expressing hSTELLA and mSTELLA, as well as the HCT116 xenograft tumor tissues from the mice treated by the indicated LNP formulations. The Infinium MethylationEPIC v2.0 array was used to obtain DNA methylation profiles across more than 935,000 CpGs in 15 samples. Samples included 3 stable NSCLC cells and 3 stable breast cancer cells expressing the STELLA orthologs, and 9 xenograft tumors from the mice with the indicated treatments.
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| Overall design |
Bisulphite converted DNA from the 15 samples were hybridised to the Infinium MethylationEPIC v2.0 Beadchip
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| Contributor(s) |
Bai W, Gu W, Cui Y, Guo H, Xia C, Baylin SB, Kong X |
| Citation(s) |
39774694 |
| |
| Submission date |
Jul 26, 2024 |
| Last update date |
Jan 09, 2025 |
| Contact name |
Wenbin Gu |
| E-mail(s) |
epoch1991@gmail.com
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| Organization name |
Guangzhou Institutes of Biomedicine and Health
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| Department |
Chinese Academy of Sciences
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| Lab |
Center for Chemical Biology and Drug Discovery
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| Street address |
190 Kaiyuan Avenue, Huangpu District, Guangzhou
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| City |
Guangzhou |
| ZIP/Postal code |
510530 |
| Country |
China |
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| Platforms (1) |
| GPL33022 |
Illumina Infinium MethylationEPIC version 2 |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA1140551 |
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