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Series GSE27206 Query DataSets for GSE27206
Status Public on Jan 04, 2013
Title Global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 compared to transcriptomic data obtained by corresponding fibroblasts
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPS cells) obtained by reprogramming SMA patient and his healthy father fibroblasts, and genetically corrected SMA-iPSC obtained converting SMN2 into SMN1 with target gene correction (TGC), were used to study gene expression and splicing events linked to pathogenetic mechanisms.
Microarray technology was used to assess global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 (Prof. J. Thomson's lab) compared to transcriptomic data obtained by corresponding fibroblasts.
 
Overall design The microarray data derived from three different individuals: SMA patient, healthy father and control iPS cells (19.9). We analyzed iPSC from SMA patient (n=2), iPS- from healthy father (n=1) and iPS-19.9 from Prof. Thomson's lab (n=3). The expression profile was compared to SMA patient's fibroblasts (n=2) and healthy father's fibroblasts (n=1)
 
Contributor(s) Corti S, Ronchi D, Riboldi G
Citation(s) 23253609
Submission date Feb 09, 2011
Last update date Mar 25, 2019
Contact name Stefania Corti
E-mail stefania.corti@unimi.it
Phone +390255033817
Organization name University of Milan
Department Neurological Sciences
Street address via F. Sforza 35
City Milan
ZIP/Postal code 20100
Country Italy
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (9)
GSM672181 SMA-iPS-01
GSM672182 SMA-iPS-02
GSM672183 WT-iPS-01
This SubSeries is part of SuperSeries:
GSE27207 Gene Expression Analysis of native and disease-corrected motor neurons from human spinal muscular atrophy induced pluripotent stem cells free of vector and transgenic sequences
Relations
BioProject PRJNA141985

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27206_RAW.tar 42.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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