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Series GSE26910 Query DataSets for GSE26910
Status Public on Mar 31, 2011
Title Stromal molecular signatures of breast and prostate cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Primary tumor growth induces host tissue responses that are believed to support and promote tumor progression. Identification of the molecular characteristics of the tumor microenvironment and elucidation of its crosstalk with tumor cells may therefore be crucial for improving our understanding of the processes implicated in cancer progression, identifying potential therapeutic targets, and uncovering stromal gene expression signatures that may predict clinical outcome. A key issue to resolve, therefore, is whether the stromal response to tumor growth is largely a generic phenomenon, irrespective of the tumor type, or whether the response reflects tumor-specific properties. To address similarity or distinction of stromal gene expression changes during cancer progression, oligonucleotide-based Affymetrix microarray technology was used to compare the transcriptomes of laser-microdissected stromal cells derived from invasive human breast and prostate carcinoma. Invasive breast and prostate cancer-associated stroma was observed to display distinct transcriptomes, with a limited number of shared genes. Interestingly, both breast and prostate tumor-specific dysregulated stromal genes were observed to cluster breast and prostate cancer patients, respectively, into two distinct groups with statistically different clinical outcomes. By contrast, a gene signature that was common to the reactive stroma of both tumor types did not have survival predictive value. Univariate Cox analysis identified genes whose expression level was most strongly associated with patient survival. Taken together, these observations suggest that the tumor microenvironment displays distinct features according to the tumor type that provides survival-predictive value.
 
Overall design 6 samples of stroma surrounding invasive breast primary tumors; 6 matched samples of normal stroma. 6 samples of stroma surrounding invasive prostate primary tumors; 6 matched samples of normal stroma.
 
Contributor(s) Planche A, Bacac M, Provero P, Fusco C, Delorenzi M, Stehle J, Stamenkovic I
Citation(s) 21611158
Submission date Jan 27, 2011
Last update date Mar 25, 2019
Contact name Paolo Provero
E-mail(s) paolo.provero@unito.it
Organization name University of Turin
Department Molecular Biotechnology and Health Sciences
Street address Via Nizza 52
City Torino
ZIP/Postal code I-10100
Country Italy
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (24)
GSM662756 prostate normal 1
GSM662757 prostate tumor 1
GSM662758 prostate normal 2
Relations
BioProject PRJNA136171

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Supplementary file Size Download File type/resource
GSE26910_RAW.tar 104.1 Mb (http)(custom) TAR (of CEL)
SRA Run SelectorHelp
Raw data provided as supplementary file
Processed data included within Sample table

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