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Series GSE268423 Query DataSets for GSE268423
Status Public on Nov 28, 2024
Title Spatial Transcriptomics and Network-Based Bioinformatics Differentiate Intestinal Phenotypes of Cardiac and Classical Necrotizing Enterocolitis
Organism Homo sapiens
Experiment type Other
Summary Classical necrotizing enterocolitis (classical NEC) is a devastating gastrointestinal disease of the neonatal period, and cardiac NEC is a subset of the disease occurring in infants with comorbid congenital heart disease. Despite nearly identical symptomatology, the two NEC subtypes may represent etiologically distinct diseases. We used spatial transcriptomics and network analyses to compare tissue regions of interest derived from surgically resected ileum of patients with cardiac and classical NEC, finding evidence classical and cardiac NEC may arise from differing etiologies.
 
Overall design Surgically resected ileum from 2 patients with cardiac NEC (14 total regions of interest) and 5 patients with classical NEC (42 total regions of interest) were used for spatial transcriptomics analysis. Roughly equal numbers of immune-rich (CD45+) and epithelial-rich (PanCK+) regions of interests were selected per patient.
 
Contributor(s) Burge KY, Chaaban H, Wren J
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Submission date May 28, 2024
Last update date Nov 28, 2024
Contact name Jonathan Wren
E-mail(s) Jonathan-Wren@omrf.org
Phone (405) 271-6989
Organization name OMRF
Department Genes & Human Disease Research Program
Street address 825 N.E. 13th Street
City Oklahoma City
State/province OK
ZIP/Postal code 73104
Country USA
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (56)
GSM8290957 Classical-CD45-F02
GSM8290958 Classical-CD45-F03
GSM8290959 Classical-CD45-F04
Relations
BioProject PRJNA1117340

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SOFT formatted family file(s) SOFTHelp
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Supplementary file Size Download File type/resource
GSE268423_AllDataHumanProtein.xlsx 86.3 Kb (ftp)(http) XLSX
GSE268423_CS13_1240_CS15_843.png.gz 66.7 Mb (ftp)(http) PNG
GSE268423_CS15_1579_CS15_1962.png.gz 17.6 Mb (ftp)(http) PNG
GSE268423_CS16_1492_1D_CS18_190_1C.png.gz 61.9 Mb (ftp)(http) PNG
GSE268423_CS17_128_3B_CS19_1149_1B.png.gz 3.9 Mb (ftp)(http) PNG
GSE268423_countsSCT.txt.gz 758.3 Kb (ftp)(http) TXT
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