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| Status |
Public on May 06, 2024 |
| Title |
IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the leading cause of death in the world. The most common and effective means to reduce these major adverse cardiovascular events (MACE), including myocardial infarction (MI) and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, little is known regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering.
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| Overall design |
scRNA-seq of atherosclerotic plaques of Apoe-/- mouse (with or without specific SMC with Ab or IgG against Il1b)
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| Contributor(s) |
Karnewar S, Karnewar V, Deaton R, Shankman LS, Benavente ED, Williams CM, Bradley X, Alencar GF, Bulut GB, Kirmani S, Baylis RA, Zunder ER, den Ruijter HM, Pasterkamp G, Owens GK |
| Citation(s) |
38695167 |
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| Submission date |
Apr 17, 2024 |
| Last update date |
May 07, 2024 |
| Contact name |
Gary K Owens |
| Organization name |
University of Virginia
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| Street address |
415 Lane Road MR5 Building Room 1322
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| City |
Charlottesville |
| State/province |
VA |
| ZIP/Postal code |
22908 |
| Country |
USA |
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| Platforms (1) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA1101548 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE264253_RAW.tar |
57.8 Mb |
(http)(custom) |
TAR (of TAR) |
SRA Run Selector |
| Raw data are available in SRA |
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