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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 29, 2024 |
| Title |
Hepatocellular carcinoma specific epigenetic checkpoint bi-directionally regulates antitumor immunity of CD4+T cell |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
To investigate the effect of Matr3 CKO of CD4+ T cells on HCC of mice.
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| Overall design |
A 25 μL mixture of PBS and Matrigel (Corning, USA) (1:1) containing 5 × 10^5 Hepa1-6 cells were injected into the left liver lobe of the C57BL/6 mice to establish the HCC orthotopic transplantation mice model. To investigate the effect of Matr3 on tumor infiltrating cells and TCR of T cell, Matr3 CKO and WT mice of CD4+ T cell carried HCC were isolated and analyzed using scRNAseq and TCRseq on the fifth and fourteenth day.
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| Contributor(s) |
Wang S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 07, 2024 |
| Last update date |
May 30, 2024 |
| Contact name |
Nan Xu |
| E-mail(s) |
22118026@zju.edu.cn
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| Phone |
15809508967
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| Organization name |
Zhejiang University
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| Street address |
Huansha Roud
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| City |
Hang Zhou |
| ZIP/Postal code |
310030 |
| Country |
China |
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| Platforms (1) |
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| Samples (16)
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| GSM8190771 |
5DKO2, scRNAseq |
| GSM8190772 |
14DCON1, scRNAseq |
| GSM8190773 |
14DCON2, scRNAseq |
| GSM8190774 |
14DKO1, scRNAseq |
| GSM8190775 |
14DKO2, scRNAseq |
| GSM8190776 |
5DCON1, TCRseq |
| GSM8190777 |
5DCON2, TCRseq |
| GSM8190778 |
5DKO1, TCRseq |
| GSM8190779 |
5DKO2, TCRseq |
| GSM8190780 |
14DCON1, TCRseq |
| GSM8190781 |
14DCON2, TCRseq |
| GSM8190782 |
14DKO1, TCRseq |
| GSM8190783 |
14DKO2, TCRseq |
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| Relations |
| BioProject |
PRJNA1097278 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE263391_RAW.tar |
953.8 Mb |
(http)(custom) |
TAR (of CSV, TAR) |
SRA Run Selector |
| Raw data are available in SRA |
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