|
| Status |
Public on May 29, 2024 |
| Title |
Effect of whole-body deletion of Gclc on the liver |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The rate-limiting step in glutathione (GSH) synthesis is controlled by glutamate-cysteine ligase catalytic subunit. To investigate the impact of GSH in vivo, we induced a deletion of Gclc using a Gclcf/f Rosa26-CreERT2 mouse model and harvested liver tissue for analysis.
|
| |
|
| Overall design |
Liver tissue was harvested from WT and KO mice approximately two weeks after treatment with tamoxifen to induce Cre activity and Gclc deletion.
|
| |
|
| Contributor(s) |
Harris IS, Asantewaa G |
| Citation(s) |
39034312 |
| |
| Submission date |
Apr 03, 2024 |
| Last update date |
Aug 16, 2024 |
| Contact name |
Isaac Spencer Harris |
| E-mail(s) |
isaac_harris@urmc.rochester.edu
|
| Phone |
8572348624
|
| Organization name |
University of Rochester Medical Center
|
| Department |
Department of Biomedical Genetics
|
| Lab |
Harris Lab
|
| Street address |
601 Elmwood Ave
|
| City |
Rochester |
| State/province |
New York |
| ZIP/Postal code |
14642 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (32)
|
|
| Relations |
| BioProject |
PRJNA1096112 |
Less...
More...