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| Status |
Public on Jul 02, 2024 |
| Title |
Aging Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease by Inducing Ferroptotic Stress |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Aging increases the risk for failure of many metabolically-stressed organs and exacerbates liver degeneration related to obesity and diabetes. We used snRNA-seq to identify the effect of metabolic disease (MASLD) on biological aging of hepatocyte.
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| Overall design |
12 weeks old C57BL/6J male mice were fed with either chow or CDA-HFD for 22 weeks, and nuclei were isolated from liver tissues for snRNA-seq analysis
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| Contributor(s) |
Du K, Wang L, Jun J, Dutta RK, Maeso-Díaz R, Oh S, Ko DC, Diehl AM |
| Citation(s) |
38918603, 40155379 |
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| Submission date |
Apr 01, 2024 |
| Last update date |
Apr 10, 2025 |
| Contact name |
Rajesh Kumar Dutta |
| E-mail(s) |
rajesh.dutta@duke.edu
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| Phone |
3126468011
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| Organization name |
Duke University
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| Department |
Gastroenterology
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| Lab |
Anna Mae Diehl's lab
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| Street address |
905 S LaSalle street, GSRB1, Rm-1063
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| City |
DURHAM |
| State/province |
NC |
| ZIP/Postal code |
27710 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1094958 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE262939_RAW.tar |
663.0 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
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