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| Status |
Public on May 26, 2024 |
| Title |
The effect of RVG-SCMH1-Evs treatment on photothrombotic (PT) stroke mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Metabolic dysfunction is considered a key event after ischemic stroke. However, the underlying mechanisms of metabolic disorders in cerebral ischemia is unknown. Circular RNA SCMH1 (circSCMH1), a circular RNA that has been reported to function in brain repair after stroke, was confirmed to be involved in metabolic disorders. circSCMH1 was delivered by rabies virus glycoprotein (RVG)-modified sxtracellular vesicle. Mechanistically, circSCMH1 decreased kynurenine 3-monooxygenase (KMO) expression, a key enzyme in kynurenine metabolism. Our findings suggested that circSCMH1 inhibited KMO expression, providing insight into the mechanism by which circSCMH1 promotes stroke recovery.
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| Overall design |
To investigate the mechanism of circular RNA SCMH1 in functional recovery of photothrombotic (PT) stroke mice.
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| Contributor(s) |
Wang Y |
| Citation(s) |
39659575 |
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| Submission date |
Mar 14, 2024 |
| Last update date |
Jan 02, 2025 |
| Contact name |
Yu Wang |
| E-mail(s) |
230218469@seu.edu.cn
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| Phone |
13913860389
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| Organization name |
Southeast University
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| Department |
Department of Pharmacology
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| Lab |
Honghong yao's lab
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| Street address |
Dingjiaqiao 87
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| City |
Nanjing |
| State/province |
Jiangsu |
| ZIP/Postal code |
210009 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| GSM8147456 |
Mouse,Sham-circSCMH1,rep1 |
| GSM8147457 |
Mouse,Sham-circSCMH1,rep2 |
| GSM8147458 |
Mouse,Sham-circSCMH1,rep3 |
| GSM8147459 |
Mouse,PT-Vector,rep1 |
| GSM8147460 |
Mouse,PT-Vector,rep2 |
| GSM8147461 |
Mouse,PT-Vector,rep3 |
| GSM8147462 |
Mouse,PT-circSCMH1,rep1 |
| GSM8147463 |
Mouse,PT-circSCMH1,rep2 |
| GSM8147464 |
Mouse,PT-circSCMH1,rep3 |
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| Relations |
| BioProject |
PRJNA1088110 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE261613_1_genes_fpkm_expression.xlsx |
8.9 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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