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Series GSE26109 Query DataSets for GSE26109
Status Public on Jan 27, 2011
Title A human transcriptome array for high-throughput clinical studies (with a comparison to RNA-seq technology) [RNA-Seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary A new high-density oligonucleotide array of the human transcriptome (GG-H array) has been developed for high-throughput and cost-effective analyses in clinical studies. This array allows comprehensive examination of gene expression and genome-wide identification of alternative splicing, as well as detection of coding SNPs and non-coding transcripts. The GG-H array was validated using samples from multiple independent preparations of human liver and muscle, and compared with results obtained from mRNA sequencing analysis. The GG-H array is highly reproducible in estimating gene and exon abundance, and is sensitive in detecting expression changes and alternative splicing. This array has been implemented in a multi-center clinical program and has generated high quality, reproducible data. When current cost, as well as sample and time requirements for sequencing are considered in the context of a required throughput of hundreds of samples per week for a clinical trial, the array provides a high-throughput and cost effective platform for clinical genomic studies.
 
Overall design Examination exon/gene expression of liver and muscle in quadraplicates using both the array technology and RNA-Seq
 
Contributor(s) Xu W, Seok J, Mindrinos M, Xiao W, Davis R, Tompkins R
Citation(s) 21317363
Submission date Dec 16, 2010
Last update date Feb 21, 2019
Contact name Weihong Xu
E-mail weihongx@stanford.edu
Organization name Stanford Genome Technology Center
Department Department of Biochemistry
Lab Ron W. Davis
Street address 855 California Ave
City Palo Alto
State/province CA
ZIP/Postal code 94304
Country USA
 
Platforms (1)
GPL9052 Illumina Genome Analyzer (Homo sapiens)
Samples (8)
GSM641418 liver1
GSM641419 liver2
GSM641420 liver3
This SubSeries is part of SuperSeries:
GSE26118 A human transcriptome array for high-throughput clinical studies (with a comparison to RNA-seq technology)
Relations
SRA SRP004903
BioProject PRJNA142297

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26109_RAW.tar 11.3 Gb (http)(custom) TAR (of TXT)
Processed data provided as supplementary file
Raw data are available in SRA

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