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Series GSE26109 Query DataSets for GSE26109
Status Public on Jan 27, 2011
Title A human transcriptome array for high-throughput clinical studies (with a comparison to RNA-seq technology) [RNA-Seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary A new high-density oligonucleotide array of the human transcriptome (GG-H array) has been developed for high-throughput and cost-effective analyses in clinical studies. This array allows comprehensive examination of gene expression and genome-wide identification of alternative splicing, as well as detection of coding SNPs and non-coding transcripts. The GG-H array was validated using samples from multiple independent preparations of human liver and muscle, and compared with results obtained from mRNA sequencing analysis. The GG-H array is highly reproducible in estimating gene and exon abundance, and is sensitive in detecting expression changes and alternative splicing. This array has been implemented in a multi-center clinical program and has generated high quality, reproducible data. When current cost, as well as sample and time requirements for sequencing are considered in the context of a required throughput of hundreds of samples per week for a clinical trial, the array provides a high-throughput and cost effective platform for clinical genomic studies.
Overall design Examination exon/gene expression of liver and muscle in quadraplicates using both the array technology and RNA-Seq
Contributor(s) Xu W, Seok J, Mindrinos M, Xiao W, Davis R, Tompkins R
Citation(s) 21317363
Submission date Dec 16, 2010
Last update date Feb 21, 2019
Contact name Weihong Xu
Organization name Stanford Genome Technology Center
Department Department of Biochemistry
Lab Ron W. Davis
Street address 855 California Ave
City Palo Alto
State/province CA
ZIP/Postal code 94304
Country USA
Platforms (1)
GPL9052 Illumina Genome Analyzer (Homo sapiens)
Samples (8)
GSM641418 liver1
GSM641419 liver2
GSM641420 liver3
This SubSeries is part of SuperSeries:
GSE26118 A human transcriptome array for high-throughput clinical studies (with a comparison to RNA-seq technology)
SRA SRP004903
BioProject PRJNA142297

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26109_RAW.tar 11.3 Gb (http)(custom) TAR (of TXT)
Processed data provided as supplementary file
Raw data are available in SRA

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