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Series GSE26085 Query DataSets for GSE26085
Status Public on Sep 15, 2011
Title BCL6 is required for the initiation and maintenance of chronic myeloid leukemia
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We identified the BCL6 protooncogene as a critical downstream effector of FoxO3A in self-renewal signaling of CML-initiating cells. BCL6 represses Arf and p53 in CML cells and is required for leukemia stem cell maintenance, colony formation and initiation of leukemia in transplant recipients. Importantly, peptide inhibition of BCL6 in human CML cells compromises colony formation and leukemia-initiation in xenotransplanted mouse recipients. These findings identify peptide-inhibition of BCL6 as a novel strategy to eradicate leukemia-initiating cells in CML.
 
Overall design Identification of BCL6 binding sites in human CML cell line JURL-MK1
 
Contributor(s) Hatzi K, Hurtz C, Müschen M
Citation(s) 21911423
Submission date Dec 15, 2010
Last update date Feb 21, 2019
Contact name Katerina Hatzi
E-mail kac2029@med.cornell.edu
Organization name WCMC
Department Hematology/Oncology
Lab Ari Melnick
Street address 413 E 69th Street, BB-1462
City New York
State/province NY
ZIP/Postal code 10021
Country USA
 
Platforms (1)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
Samples (2)
GSM640427 BCL6_ChIPSeq
GSM640428 INPUT_Seq
Relations
SRA SRP004887
BioProject PRJNA135225

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26085_RAW.tar 2.1 Gb (http)(custom) TAR (of BED, TXT, WIG)
Raw data are available in SRA
Processed data provided as supplementary file

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