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Series GSE25636 Query DataSets for GSE25636
Status Public on Jul 10, 2012
Title A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor cells. In Sca1-MALT1 mice, MALT1 deregulation activated the NF-kappaB pathway in Sca1+ cells, promoting selective B-cell differentiation and mature lymphocyte accumulation in extranodal tissues, progressively leading to the development of clonal B-cell lymphomas. These tumors recapitulated the histopathological features of human MALT lymphomas, presenting typical lymphoepithelial lesions and plasmacytic differentiation. Transcriptional profiling of Sca1-MALT1 murine lymphomas revealed overlapping molecular signatures with human MALT lymphomas, including MALT1-mediated NFkappaB activation, pro-inflammatory signaling and XBP1-induced plasmacytic differentiation. Moreover, murine Malt1 showed proteolytic activity by cleaving Bcl10 in Sca1-MALT1 lymphomas. Our novel technological approach has allowed modeling human MALT lymphoma in mice, which represent unique tools study MALT lymphoma biology and evaluate anti-MALT1 therapies.

Keywords: Genetic modification, wt vs. transgenic, MALT1 expression
 
Overall design 8 sorting purified Sca1+Lin- samples were analized of which 5 were from Sca1-MALT1 transgenic mice and 3 were from WT mice.
 
Contributor(s) Vicente-Dueñas C, Fontán L, Gonzalez-Herrero I, Segura V, Aznar A, Alonso-Escudero E, Martinez-Ferrandis JI, Abollo-Jimenez F, Bertolo C, Garcia-Criado FJ, García-Cenador MB, Garcia-Bragado F, Remstein ED, Siebert R, Du MQ, Sagaert X, Lossos IS, Flores T, Cobaleda C, Sanchez-Garcia I, Martinez-Climent JA
Citation(s) 22689981
Submission date Nov 28, 2010
Last update date Feb 11, 2019
Contact name Victor Segura
E-mail(s) vsegura@unav.es
Organization name FIMA
Department Unit of Proteomics, Genomics and Bioinformatics
Street address Avda. Pío XII, 55
City Pamplona
State/province Navarra
ZIP/Postal code 31008
Country Spain
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (8)
GSM629877 WT_Sca1+Lin-_1
GSM629878 WT_Sca1+Lin-_2
GSM629879 WT_Sca1+Lin-_3
This SubSeries is part of SuperSeries:
GSE25639 A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma
Relations
BioProject PRJNA142419

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25636_RAW.tar 29.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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