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Series GSE25636 Query DataSets for GSE25636
Status Public on Jul 10, 2012
Title A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor cells. In Sca1-MALT1 mice, MALT1 deregulation activated the NF-kappaB pathway in Sca1+ cells, promoting selective B-cell differentiation and mature lymphocyte accumulation in extranodal tissues, progressively leading to the development of clonal B-cell lymphomas. These tumors recapitulated the histopathological features of human MALT lymphomas, presenting typical lymphoepithelial lesions and plasmacytic differentiation. Transcriptional profiling of Sca1-MALT1 murine lymphomas revealed overlapping molecular signatures with human MALT lymphomas, including MALT1-mediated NFkappaB activation, pro-inflammatory signaling and XBP1-induced plasmacytic differentiation. Moreover, murine Malt1 showed proteolytic activity by cleaving Bcl10 in Sca1-MALT1 lymphomas. Our novel technological approach has allowed modeling human MALT lymphoma in mice, which represent unique tools study MALT lymphoma biology and evaluate anti-MALT1 therapies.

Keywords: Genetic modification, wt vs. transgenic, MALT1 expression
Overall design 8 sorting purified Sca1+Lin- samples were analized of which 5 were from Sca1-MALT1 transgenic mice and 3 were from WT mice.
Contributor(s) Vicente-Dueñas C, Fontán L, Gonzalez-Herrero I, Segura V, Aznar A, Alonso-Escudero E, Martinez-Ferrandis JI, Abollo-Jimenez F, Bertolo C, Garcia-Criado FJ, García-Cenador MB, Garcia-Bragado F, Remstein ED, Siebert R, Du MQ, Sagaert X, Lossos IS, Flores T, Cobaleda C, Sanchez-Garcia I, Martinez-Climent JA
Citation(s) 22689981
Submission date Nov 28, 2010
Last update date Feb 11, 2019
Contact name Victor Segura
Organization name FIMA
Department Unit of Proteomics, Genomics and Bioinformatics
Street address Avda. Pío XII, 55
City Pamplona
State/province Navarra
ZIP/Postal code 31008
Country Spain
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (8)
GSM629877 WT_Sca1+Lin-_1
GSM629878 WT_Sca1+Lin-_2
GSM629879 WT_Sca1+Lin-_3
This SubSeries is part of SuperSeries:
GSE25639 A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma
BioProject PRJNA142419

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25636_RAW.tar 29.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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