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| Status |
Public on Apr 15, 2024 |
| Title |
Spatiotemporal transcriptomic changes of human ovarian aging and the key regulatory role of FOXP1 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
The understanding of how aging affects the cellular and molecular components of the human ovary and contributes to age-related fertility decline is still limited. Here, we systematically characterize human ovarian aging by combining single-cell RNA sequencing and spatial transcriptomics. We provide a comprehensive understanding of human ovarian aging and a resource for the development of new diagnostic biomarkers and therapeutic strategies.
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| Overall design |
The ovarian tissues of the 15 cases were divided into 3 groups based on ovarian function: young group (Y, 18-28 y), middle-aged group (M, 36-39 y), and old group (O, 47-49 y). We generated scRNA-seq data for 9 ovarian tissues (from 9 women) and ST-seq data for 28 ovarian tissues (from 15 women).
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| Contributor(s) |
Wang S, Wu M, Tang W |
| Citation(s) |
38594460 |
| BioProject |
PRJNA1075210 |
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| Submission date |
Feb 13, 2024 |
| Last update date |
Apr 16, 2024 |
| Contact name |
Shixuan Wang |
| E-mail(s) |
shixuanwang@tjh.tjmu.edu.cn
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| Organization name |
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
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| Street address |
Jiefang Avenue
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| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430030 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (24)
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| GSM8077819 |
Ovary,middle-2,scRNAseq |
| GSM8077820 |
Ovary,middle-3,scRNAseq |
| GSM8077821 |
Ovary,middle-4,scRNAseq |
| GSM8077822 |
Ovary,old-1,scRNAseq |
| GSM8077823 |
Ovary,old-2,scRNAseq |
| GSM8077824 |
Ovary,old-3,scRNAseq |
| GSM8077825 |
Ovary,young-1,spatial |
| GSM8077826 |
Ovary,young-2,spatial |
| GSM8077827 |
Ovary,young-3,spatial |
| GSM8077828 |
Ovary,young-4,spatial |
| GSM8077829 |
Ovary,young-5,spatial |
| GSM8077830 |
Ovary,middle-1,spatial |
| GSM8077831 |
Ovary,middle-2,spatial |
| GSM8077832 |
Ovary,middle-3,spatial |
| GSM8077833 |
Ovary,middle-4,spatial |
| GSM8077834 |
Ovary,middle-5,spatial |
| GSM8077835 |
Ovary,old-1,spatial |
| GSM8077836 |
Ovary,old-2,spatial |
| GSM8077837 |
Ovary,old-3,spatial |
| GSM8077838 |
Ovary,old-4,spatial |
| GSM8077839 |
Ovary,old-5,spatial |
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| Supplementary file |
Size |
Download |
File type/resource |
| GSE255690_RAW.tar |
909.9 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
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