|
| Status |
Public on Feb 09, 2024 |
| Title |
scRNA-seq for stromal Lkb1 deficiency-induced gastrointestinal polyps |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Numerous studies have showed that mesenchymal-specific Lkb1 is sufficient for the development of PJS-like polyps in mice. However, the cellular origin and component of these Lkb1-associated polyps and underlying mechanisms remain elusive. In this present study, we generated tamoxifen-inducible Lkb1flox/flox;Myh11-Cre/ERT2 mice and performed scRNA-seq to investigate the cellular complexity of gastrointestinal polyps associated with PJS.
|
| |
|
| Overall design |
Polyps tissues from three Lkb1flox/+;Myh11-Cre/ERT2 mice and normal duodenum tissues of three Lkb1+/+;Myh11-Cre/ERT2 (WT) mice were collected.
|
| |
|
| Contributor(s) |
Cai Z, Jiang Y, Liang M, Huang Y, He B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 12, 2024 |
| Last update date |
Feb 10, 2024 |
| Contact name |
Yijie Huang |
| E-mail(s) |
540290682@sjtu.edu.cn
|
| Phone |
+8615759698127
|
| Organization name |
Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
|
| Department |
Cardiology
|
| Lab |
ben He
|
| Street address |
上海市徐汇区淮海西路241号
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200030 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (2) |
|
| Relations |
| BioProject |
PRJNA1064124 |
