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Series GSE252409 Query DataSets for GSE252409
Status Public on Feb 03, 2025
Title Molecular profiling of brainstem peptidergic neurons
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Hunger is a fundamental drive, evolutionarily hard-wired to ensure that an animal has sufficient energy to survive and reproduce. Just as important as knowing when to eat is for an animal to know when not to eat. Here, using spatially resolved, single cell translational phenotyping and ensemble-level molecular profiling, we characterize a small population of neuropeptidergic neurons in the brainstem’s dorsal raphe nucleus (DRN) and describe how they regulate appetite. Together, this work identifies a likely conserved cellular mechanism that transforms diverse neurohumoral signals into a key behavioral output.
 
Overall design Molecular profiling of brainstem peptidergic neurons using viral TRAP (vTRAP) in tandem with high-throughput RNA sequencing.
 
Contributor(s) Nectow AR, Chowdhury S
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Submission date Jan 02, 2024
Last update date Feb 03, 2025
Contact name Alexander R Nectow
E-mail(s) arn2136@columbia.edu
Organization name Columbia University
Department Medicine
Lab Nectow Lab - P&S 8-425
Street address 630 W 168th St., Physicians and Surgeons
City New York
State/province New York
ZIP/Postal code 10032
Country USA
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM8001013 GFP IP from CCK neurons_1
GSM8001014 GFP IP from CCK neurons_2
GSM8001015 Total RNA from DRN_1
Relations
BioProject PRJNA1060350

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE252409_DESeq2_kallisto_AS005_AS006_vs_AS002_AS003-DEG_list.csv.gz 751.3 Kb (ftp)(http) CSV
GSE252409_est_counts_genes_kallisto_GEO.xlsx 1.1 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA

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