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Series GSE25065 Query DataSets for GSE25065
Status Public on May 11, 2011
Title Validation cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer.
METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcome based on estrogen receptor (ER) status,pathologic response to chemotherapy, 3-year disease outcomes, and sensitivity to endocrine therapy. Tumors were classified as treatment-sensitive if predicted to have pathologic response (and not resistance) to chemotherapy, or sensitive to endocrine therapy. We tested predictive accuracy, with 95% confidence interval (CI), for pathologic response (PPV, positive predictive value), distant relapse-free survival (DRFS), and absolute risk reduction at median follow-up in 198 other patients. Independence from clinical-pathologic factors was assessed in a multivariate Cox regression analysis based on the likelihood ratio test. Other evaluable, published response predictors (genomic grade index (GGI), intrinsic subtype (PAM50), pCR predictor (DLDA30)) were compared.
Overall design Neoadjuvant validation cohort of 198 HER2-negative breast cancer cases treated with taxane-anthracycline chemotherapy pre-operatively and endocrine therapy if ER-positive. Response was assessed at the end of neoadjuvant treatment and distant-relapse-free survival was followed for at least 3 years post-surgery.
Contributor(s) Symmans WF, Holmes F, Vidaurre T, Martin M, Souchon E
Citation(s) 21558518
Submission date Nov 01, 2010
Last update date Aug 10, 2018
Contact name Christos Hatzis
Phone 781-938-3830
Organization name Nuvera Biosciences
Street address 400 West Cummings Park, Suite 5350
City Woburn
State/province MA
ZIP/Postal code 01801
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (198)
GSM615631 1
GSM615632 5
GSM615633 12
This SubSeries is part of SuperSeries:
GSE25066 Genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
BioProject PRJNA142731

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Supplementary file Size Download File type/resource
GSE25065_RAW.tar 413.3 Mb (http)(custom) TAR (of CEL)
SRA Run SelectorHelp
Raw data provided as supplementary file
Processed data included within Sample table

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