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Series GSE24873 Query DataSets for GSE24873
Status Public on Oct 19, 2011
Title IL-17-induced NF-kB activation via CIKS/Act1: Physiologic significance and signaling mechanisms
Organism Mus musculus
Experiment type Expression profiling by array
Summary Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also contributes significantly to inflammatory and autoimmune disease pathologies. Binding of IL-17 to its receptor leads to recruitment of the adaptor protein CIKS/Act1 via heterotypic association of their respective SEFIR domains and to activation of the transcription factor NF-kB; it is not known whether CIKS and/or NF-kB are required for all gene induction events. Here we report that CIKS is essential for all IL-17 induced immediate-early genes in primary mouse embryo fibroblasts, while NF-kB is profoundly involved.  We also identify a novel sub-domain in the N-terminus of CIKS that is essential for IL-17-mediated NF-kB activation. This domain is both necessary and sufficient for the interaction between CIKS and TRAF6, an adaptor required for NF-kB activation.  The ability of decoy peptides to block this interaction may provide a new therapeutic strategy for intervention in IL-17-driven autoimmune and inflammatory diseases.

Keywords: strain comparisons
Overall design strain comparisons
Contributor(s) Sønder SU, Saret S, Tang W, Sturdevant DE, Porcella SF, Siebenlist U
Citation(s) 21335551
Submission date Oct 21, 2010
Last update date Feb 11, 2019
Contact name Dan Sturdevant
Phone 4063639248
Organization name NIH
Department NIAID
Street address 903 S 4th street
City Hamilton
State/province MT
ZIP/Postal code 59840
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (48)
GSM611612 KO-IL17 treatment replicate-1
GSM611613 KO-IL17 treatment replicate-2
GSM611614 KO-IL17 treatment replicate-3
BioProject PRJNA132013

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24873_RAW.tar 211.6 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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