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| Status |
Public on Mar 18, 2024 |
| Title |
ASH2L mediates epidermal differentiation and hair follicle morphogenesis via the regulation of the Notch signaling pathway activity [CUT&Tag] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
To elucidate the role of H3K4 methylation in epidermal development, we conditionally knocked out ASH2L, the core subunit of the COMPASS complex, in mouse epidermal progenitor (EP) cells. Then, we performed H3K4me3 modification profiling of FACS-sorted integrin α6-positive epidermal progenitor cells in P0 control mice (K14Cre,Ash2lF/+) by CUT&Tag-seq.
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| Overall design |
We performed H3K4me3 modification profiling of FACS-sorted integrin α6-positive EP cells in P0 control mice (K14Cre,Ash2lF/+) by CUT&Tag-seq.
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| Contributor(s) |
Wang Q, Zeng S, Liang Y, Zhou R, Wang D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 19, 2023 |
| Last update date |
Mar 19, 2024 |
| Contact name |
Qirui Wang |
| E-mail(s) |
dr.wangqr@gmail.com
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| Organization name |
Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
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| Department |
Department of Plastic and Reconstructive Surgery
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| Street address |
639 Zhi Zao Ju Road
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| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200011 |
| Country |
China |
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| Platforms (1) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE245774 |
ASH2L mediates epidermal differentiation and hair follicle morphogenesis via the regulation of the Notch signaling pathway activity |
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| Relations |
| BioProject |
PRJNA1029952 |
