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Series GSE24575 Query DataSets for GSE24575
Status Public on Jan 20, 2012
Title beta-arrestin-2 deficiency effect on intestinal tumorigenesis in Apc-mutated mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Amoung their pleiotropic functions, a role was recently assigned for b-arrestin scaffold proteins in tumor growth, angiogenesis and invasion. In order to elucidate the roles of b-arrestins in tumour developement in intestinal epithelium initiated by Apc mutation, we determined the effects of b-arrestin gene deletion on intestinal polypolis using ApcD14/+ mice, a relevant mouse model of human intestinal tumorigenesis.Here we show that unlike b-arrestin1, absence of b-arrestin2 dramatically decreased the number of spontaneously developping intestinal tumors in ApcD14/+ mice.The size of residual tumors was similarto that of controls, suggesting that their growth is b-arrestin2-independent. This result demonstrated a role for b-arrestin2 in the early development of a tumor subset. Gene expression profils analysis of ApcD14/+:Arrb2+/+ and ApcD14/+:Arrb2-/- tumors showed two distinct clusters among ApcD14/+:Arrb2+/+ tumors and one of them was statistically more correlated to ApcD14/+:Arrb2-/- tumors than to the other ApcD14/+:Arrb2+/+ cluster, eventhough a number of genes saw their expression affected in ApcD14/+:Arrb2-/- tumors only. Altogether, our data unravel an unexpected early diversity among intestinal tumors and a crucial role for b-arrestin2 in early tumor development in Apc-mutated mice.
 
Overall design 16 tumors from ApcD14/+:Arrb2+/+ mice and 13 tumors from ApcD14/+:Arrb2-/- mice
 
Contributor(s) Bonnans C, Falceliere M, Dantec C, Devignes J, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D
Citation(s) 22315403
Submission date Oct 07, 2010
Last update date Mar 22, 2012
Contact name Caroline Bonnans
E-mail(s) cbonnans@univ-montp1.fr
Phone +33-4-67-66-81-60
Organization name Functional Genomic Institute
Department Oncology
Street address 141 rue de la Cardonille
City Montpellier
ZIP/Postal code 34094
Country France
 
Platforms (1)
GPL10994 NimbleGen Mus musculus MM9 Expression Array (12x135k)_ALL PROBES
Samples (29)
GSM605714 Tumor from ApcD14/+:Arrb2+/+ mouse 1
GSM605715 Tumor from ApcD14/+:Arrb2+/+ mouse 2
GSM605716 Tumor from ApcD14/+:Arrb2+/+ mouse 3
This SubSeries is part of SuperSeries:
GSE24577 Impact of beta-arrestin-2 deficiency on intestinal tumorigenesis in Apc-mutated mice
Relations
BioProject PRJNA133595

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24575_RAW.tar 107.7 Mb (http)(custom) TAR (of PROBE)
Processed data included within Sample table
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