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Series GSE24493 Query DataSets for GSE24493
Status Public on Oct 10, 2010
Title Effect of Imatinib on chronic myelogenous leukemia
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which is present in almost every patient with chronic myeloid leukemia. In this study, the tyrosine kinase inhibitor Imatinib was used for pharmacological inhibition of BCR-ABL1. Gene expression profiles of CML cell lines were analyzed in response to Imatinib treatment.
Overall design Three CML cell lines (KU-812, KCL-22, JURL-MK1) were either treated with 10 µM STI571 (Imatinib) for 16 hours or cultured in absence of STI571.
Contributor(s) Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon S, Nahar R, Braig M, Park E, Kim Y, Hofmann W, Herzog S, Jumaa H, Koeffler PH, Yu JJ, Heisterkamp N, Wu H, Ye HB, Melnick A, Müschen M
Citation(s) 21593872, 21911423
Submission date Oct 03, 2010
Last update date Jan 08, 2019
Contact name Markus Müschen
Phone + 1 323 361 5592
Fax +1 323 361 1516
Organization name University of Southern California
Department Childrens Hospital Los Angeles
Lab Müschen Lab
Street address 4650 Sunset Blvd
City Los Angeles
State/province CA
ZIP/Postal code 90027
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (6)
GSM603097 KCL-22 non-treated
GSM603098 KCL-22 Imatinib-treated
GSM603099 KU-812 non-treated
BioProject PRJNA132497

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24493_RAW.tar 28.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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