|
| Status |
Public on Oct 03, 2023 |
| Title |
Myeloid Cell Derived IL1b Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Goals and objectives of this study were to determine on a single-cell level transcriptomic changes that occur in the lungs of a murine model of heart failure with preserved ejection fraction caused by administration of high fat diet and eNOS inhibitor L-NAME.
|
| |
|
| Overall design |
Four C57/BL6 mice each were given either a combination of high fat diet and L-NAME or control (low fat diet with no L-NAME) for 5 weeks. Lungs were isolated after sacrifice, enzymatically digested, separately labeled with hashing antibodies, and submitted for single cell RNA sequencing.
|
| |
|
| Contributor(s) |
Agrawal V, Kropski J, West J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 28, 2023 |
| Last update date |
Oct 03, 2023 |
| Contact name |
Vineet Agrawal |
| E-mail(s) |
vineet.agrawal@vumc.org
|
| Organization name |
Veterans Affairs Hospital in Nashville, TN
|
| Street address |
1310 24th Ave South
|
| City |
Nashville |
| ZIP/Postal code |
37212 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (2) |
|
| Relations |
| BioProject |
PRJNA1022305 |
