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Series GSE24400 Query DataSets for GSE24400
Status Public on Sep 29, 2010
Title Comparison of copy number variations between wildtype and BCL6 knockout BCR-ABL1-driven acute lymphoblastic leukemia
Organism Mus musculus
Experiment type Genome variation profiling by genome tiling array
Summary This comparative genomic hybridization (CGH) study investigated the effect of BCL6 on clonal evolution in BCR-ABL1-driven acute lymphoblastic leukemia (ALL). The frequencies of copy number alterations in BCR-ABL1-transformed BCL6+/+ and BCL6-/- leukemias were determined.
Overall design Three BCR-ABL1-transformed BCL6+/+ and BCL6-/- ALL samples derived from mice were maintained for 4 month in cell culture and were subjected to CGH analysis. As control samples, normal untransformed splenoytes were used.
Contributor(s) Duy C, Hurtz C, Cerchietti L, Klemm L, Swaminathan S, Shojaee S, Ci W, Geng H, Braig M, Hofmann W, Koeffler HP, Yu JJ, Nahar R, Kweon S, Hennighausen L, Herzog S, Jumaa H, Groffen J, Heisterkamp N, Ye BH, Melnick AM, Müschen M
Citation(s) 21593872
Submission date Sep 28, 2010
Last update date Mar 22, 2012
Contact name Markus Müschen
Phone + 1 323 361 5592
Fax +1 323 361 1516
Organization name University of Southern California
Department Childrens Hospital Los Angeles
Lab Müschen Lab
Street address 4650 Sunset Blvd
City Los Angeles
State/province CA
ZIP/Postal code 90027
Country USA
Platforms (1)
GPL10989 NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array (Build MM9) [080603_MM9_WG_CGH_HX3]
Samples (6)
GSM601419 Bcl6 +/+ BCR-ABL1-driven ALL 1
GSM601420 Bcl6 +/+ BCR-ABL1-driven ALL 2
GSM601421 Bcl6 +/+ BCR-ABL1-driven ALL 3
BioProject PRJNA132953

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24400_RAW.tar 354.6 Mb (http)(custom) TAR (of PAIR, TXT)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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