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Series GSE24363 Query DataSets for GSE24363
Status Public on Sep 25, 2010
Title MAQC-II Project: NIEHS data set
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary The NIEHS data set (endpoint C) was provided by the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (Research Triangle Park, NC, USA). The study objective was to use microarray gene expression data acquired from the liver of rats exposed to hepatotoxicants to build classifiers for prediction of liver necrosis. The gene expression compendium data set was collected from 418 rats exposed to one of eight compounds (1,2-dichlorobenzene, 1,4-dichlorobenzene, bromobenzene, monocrotaline, N-nitrosomorpholine, thioacetamide, galactosamine, and diquat dibromide). All eight compounds were studied using standardized procedures, i.e. a common array platform (Affymetrix Rat 230 2.0 microarray), experimental procedures and data retrieving and analysis processes.
 
Overall design For each compound, four to six male, 12 week old F344 rats were exposed to a low dose, mid dose(s) and a high dose of the toxicant and sacrificed at 6, 24 and 48 hrs later. At necropsy, liver was harvested for RNA extraction, histopathology, and clinical chemistry assessments.
 
Citation(s) 20064235, 20676074
Submission date Sep 24, 2010
Last update date Jul 31, 2017
Contact name Leming Shi
E-mail(s) leming.shi@gmail.com
Phone +86-18616827008
Organization name Fudan Univresity
Department School of Life Sciences
Lab Center for Pharmacogenomics
Street address 2005 Songhu Road
City Shanghai
ZIP/Postal code 200438
Country China
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (418)
GSM600444 liver; 1, 2-Dichlorobenzene; 0 mg/kg; 6 hours; 210759875_33326
GSM600445 liver; 1, 2-Dichlorobenzene; 0 mg/kg; 6 hours; 210759876_33331
GSM600446 liver; 1, 2-Dichlorobenzene; 0 mg/kg; 6 hours; 210759877_33317
This SubSeries is part of SuperSeries:
GSE16716 MicroArray Quality Control Phase II (MAQC-II) Project
Relations
BioProject PRJNA132825

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24363_RAW.tar 1.6 Gb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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