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Series GSE24250 Query DataSets for GSE24250
Status Public on Sep 01, 2011
Title The transcriptional modulator H2AFY marks Huntington's disease activity in men and mice
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To accelerate the development of disease-modifying therapeutics for Huntington’s disease (HD), a dynamic biomarker of disease activity and treatment response is critically needed.
 
Overall design Venous cellular whole blood from 8 patients with Huntington's disease (HD) and 6 control subjects were collected in PAXgene tubes (Wiagen, Valencia, CA). RNA was isolated from whole blood using the PAXgene blood RNA kit (Qiagene) with DNase treatment. The biotinylated complementary RNA was fragmented and hybridized to Affymetrix human genome U133A microarrays. The Affymetrix .CEL files were normalized to “all probe sets” in a standardized matter, and scaled to 100 by the MAS5 5.0 algorithm implemented in the Bioconductor package.
 
Contributor(s) Scherzer CR, Hu Y, Liao Z, Zheng B
Citation(s) 21969577
Submission date Sep 21, 2010
Last update date Aug 10, 2018
Contact name Bin Zheng
Organization name Brigham and Women's hospital
Department Center for Neurologic Diseases
Street address 65 Landsdowne Street
City Cambridge
State/province MA
ZIP/Postal code 02139
Country USA
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (14)
GSM596529 Control 820B
GSM596530 Huntington's disease 820C
GSM596531 Huntington's disease 820D
Relations
BioProject PRJNA133053

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24250_RAW.tar 45.7 Mb (http)(custom) TAR (of CEL)
SRA Run SelectorHelp
Raw data provided as supplementary file
Processed data included within Sample table

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