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Series GSE242255 Query DataSets for GSE242255
Status Public on Sep 11, 2023
Title DNA-PKcs is a key transcriptional and splicing regulator of AR-Vs in advanced prostate cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To investigate the role of DNA-PKcs and RBMX in the regulation of androgen receptor variants we used the CWR22Rv1-AR-EK and CWR22Rv1 cell line in which DNA-PKcs or RBMX has been knocked down by siRNA or DNA-PKcs was inhibited with 1 µM NU7441, NU5455 or AZD7648. We then performed gene expression analysis using data obtained from RNA-seq at two time points (72 hours knockdown and 24 hours drug treatment).
 
Overall design Comparative gene expression profiling analysis of RNA-seq data for CWR22Rv1-AR-EK and CWR22Rv1 cells.
 
Contributor(s) Gaughan L, Adamson B, Brittain N
Citation(s) 37751307
Submission date Sep 04, 2023
Last update date Dec 07, 2023
Contact name Beth Adamson
E-mail(s) beth.adamson@ncl.ac.uk
Organization name Newcastle University
Department Translational and Clinical Research Institute
Lab Gaughan Lab
Street address Paul O'Gorman Building, Framlington Place
City Newcastle upon Tyne
ZIP/Postal code NE2 4HH
Country United Kingdom
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (21)
GSM7757195 CWR22Rv1-AR-EK cells 72h Scrambled siRNA/24h DMSO n1
GSM7757196 CWR22Rv1-AR-EK cells 72h Scrambled siRNA/24h DMSO n2
GSM7757197 CWR22Rv1-AR-EK cells 72h Scrambled siRNA/24h DMSO n3
Relations
BioProject PRJNA1012715

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE242255_AREK_DNAPK_DESeq2_normalised_counts.csv.gz 2.6 Mb (ftp)(http) CSV
GSE242255_AREK_DNAPK_featureCounts.tsv.gz 3.9 Mb (ftp)(http) TSV
GSE242255_Rv1_RBMX_DESeq2_normalised_counts.csv.gz 1.5 Mb (ftp)(http) CSV
GSE242255_Rv1_RBMX_featureCounts.tsv.gz 3.7 Mb (ftp)(http) TSV
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