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Status |
Public on Jul 17, 2024 |
Title |
The murine 900 kb downsteam region from Gata3 interacts to the transciption start site and three enhancers in Th2 cells. |
Organism |
Mus musculus |
Experiment type |
Other
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Summary |
Murine counterpart of the region (mG900 region), in which SNPs associated with human asthma are enriched, is located 900 kb downstream from the transcription start site (TSS) of Gata3. Gata3-TSS interacted with mG900 region in only cultured Th2 cells but not in naive CD4 T cells or cultured Th0 cells. The mG900-deficient Th2 cells exhibited reduced interaction between Gata3-TSS and three enhancers.
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Overall design |
4C-seq were perfromed for cultured CD4 T cells using two baits of transcription start site of Gata3 and the region located at 932 downstream from Gata3.
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Contributor(s) |
Iwata A, Okabe A |
Citation(s) |
38923989 |
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Submission date |
Aug 30, 2023 |
Last update date |
Jul 18, 2024 |
Contact name |
Arifumi Iwata |
Organization name |
Chiba University
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Department |
Department of Allergy and Clinical Immunology
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Street address |
1-8-1 Inohana, Chuou-ku
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City |
Chiba-shi |
State/province |
Chiba |
ZIP/Postal code |
260-8670 |
Country |
Japan |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (7)
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Relations |
BioProject |
PRJNA1010862 |