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| Status |
Public on Jul 17, 2024 |
| Title |
The murine 900 kb downsteam region from Gata3 interacts to the transciption start site and three enhancers in Th2 cells. |
| Organism |
Mus musculus |
| Experiment type |
Other
|
| Summary |
Murine counterpart of the region (mG900 region), in which SNPs associated with human asthma are enriched, is located 900 kb downstream from the transcription start site (TSS) of Gata3. Gata3-TSS interacted with mG900 region in only cultured Th2 cells but not in naive CD4 T cells or cultured Th0 cells. The mG900-deficient Th2 cells exhibited reduced interaction between Gata3-TSS and three enhancers.
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| Overall design |
4C-seq were perfromed for cultured CD4 T cells using two baits of transcription start site of Gata3 and the region located at 932 downstream from Gata3.
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| Contributor(s) |
Iwata A, Okabe A |
| Citation(s) |
38923989 |
| |
| Submission date |
Aug 30, 2023 |
| Last update date |
Jul 18, 2024 |
| Contact name |
Arifumi Iwata |
| Organization name |
Chiba University
|
| Department |
Department of Allergy and Clinical Immunology
|
| Street address |
1-8-1 Inohana, Chuou-ku
|
| City |
Chiba-shi |
| State/province |
Chiba |
| ZIP/Postal code |
260-8670 |
| Country |
Japan |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA1010862 |
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