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| Status |
Public on Jan 26, 2025 |
| Title |
ACSS2 mediates an epigenetic pathway to regulate maternal β-cell adaptation and progression of gestational diabetes (ATAC-seq and CUT&RUN) |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Maternal pancreatic β-cell state is adapted to accommodate gestation metabolism. Defects in this process may cause gestational diabetes mellitus (GDM), with risk factors including a high-calorie diet during pregnancy. However, the regulatory mechanism of maternal β-cell adaptation is largely unknown. Using single-cell transcriptome combining genetic analyses, we discovered a precise process of β-cell adaptation in mice which is associated with progression of metabolic stress-related β-cell dysfunction, increased acetyl-CoA biosynthesis, and gene element-specific histone acetylation. STAT3 recruits p300 to promote histone acetylation levels of pregnancy-associated genes, and Acetyl-CoA Synthetase 2 (ACSS2) enhances this process. High-fat feeding causes hyperacetylation of chromatin that is specifically opened during pregnancy, which results in overexpression of genes that impair β-cell functions and, consequently, hyperglycemia. However, these impairments can be rescued by β-cell-specific deletion of Acss2. Therefore, our study reveals a precise adaptation process in β-cells at the single-cell level during pregnancy and a specific epigenetic pathway that regulates this process. We also explain the epigenetic regulatory mechanism by which a high-fat diet can lead to GDM and identify ACSS2 as a potential molecular target for controlling the progression of GDM.
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| |
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| Overall design |
ChIP-seq and ATAC-seq of mouse pancreatic islets during gestation and puerperium days.
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| |
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| Contributor(s) |
Xu C, Zhang Y, He S, Wang X, Wang X, He M, Yu X |
| Citation(s) |
40393969 |
| |
| Submission date |
Aug 28, 2023 |
| Last update date |
May 21, 2025 |
| Contact name |
Cheng-ran Xu |
| Organization name |
Peking University
|
| Department |
School of Basic Medical Sciences
|
| Street address |
NO.5 YIHEYUAN ROAD HAIDIAN DISTRICT, BEIJING, P.R.CHINA
|
| City |
Beijing |
| State/province |
- |
| ZIP/Postal code |
100871 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (69)
|
| GSM7743327 |
pancreatic β cell, G0, ATAC-seq, biol rep1 |
| GSM7743328 |
pancreatic β cell, G0, ATAC-seq, biol rep2 |
| GSM7743329 |
pancreatic β cell, G14.5, ATAC-seq, biol rep1 |
| GSM7743330 |
pancreatic β cell, G14.5, ATAC-seq, biol rep2 |
| GSM7743331 |
pancreatic β cell, P7NL, ATAC-seq, biol rep1 |
| GSM7743332 |
pancreatic β cell, P7NL, ATAC-seq, biol rep2 |
| GSM7743333 |
pancreatic β cell, HFDG0, ATAC-seq, biol rep1 |
| GSM7743334 |
pancreatic β cell, HFDG0, ATAC-seq, biol rep2 |
| GSM7743335 |
pancreatic β cell, HFDG14.5, ATAC-seq, biol rep1 |
| GSM7743336 |
pancreatic β cell, HFDG14.5, ATAC-seq, biol rep2 |
| GSM7743337 |
pancreatic β cell, G0, H3K27ac, biol rep1 |
| GSM7743338 |
pancreatic β cell, G0, H3K27ac, biol rep2 |
| GSM7743339 |
pancreatic β cell, G14.5, H3K27ac, biol rep1 |
| GSM7743340 |
pancreatic β cell, G14.5, H3K27ac, biol rep2 |
| GSM7743341 |
pancreatic β cell, P7NL, H3K27ac, biol rep1 |
| GSM7743342 |
pancreatic β cell, P7NL, H3K27ac, biol rep2 |
| GSM7743343 |
pancreatic β cell, G18.5Acss2KO, H3K27ac, biol rep1 |
| GSM7743344 |
pancreatic β cell, G18.5Acss2KO, H3K27ac, biol rep2 |
| GSM7743345 |
pancreatic β cell, G18.5Acss2KO, H3K27ac, rep3 |
| GSM7743346 |
pancreatic β cell, G18.5Acss2WT, H3K27ac, biol rep1 |
| GSM7743347 |
pancreatic β cell, G18.5Acss2WT, H3K27ac, biol rep2 |
| GSM7743348 |
pancreatic β cell, G18.5Acss2WT, H3K27ac, rep3 |
| GSM7743349 |
pancreatic β cell, G18.5Stat3KO, H3K27ac, biol rep1 |
| GSM7743350 |
pancreatic β cell, G18.5Stat3KO, H3K27ac, biol rep2 |
| GSM7743351 |
pancreatic β cell, G18.5Stat3KO, H3K27ac, rep3 |
| GSM7743352 |
pancreatic β cell, G18.5Stat3WT, H3K27ac, biol rep1 |
| GSM7743353 |
pancreatic β cell, G18.5Stat3WT, H3K27ac, biol rep2 |
| GSM7743354 |
pancreatic β cell, G18.5Stat3WT, H3K27ac, rep3 |
| GSM7743355 |
pancreatic β cell, HFDG0, H3K27ac, biol rep1 |
| GSM7743356 |
pancreatic β cell, HFDG0, H3K27ac, biol rep2 |
| GSM7743357 |
pancreatic β cell, HFDG14.5Acss2KO, H3K27ac, biol rep1 |
| GSM7743358 |
pancreatic β cell, HFDG14.5Acss2KO, H3K27ac, biol rep2 |
| GSM7743359 |
pancreatic β cell, HFDG14.5WT, H3K27ac, biol rep1 |
| GSM7743360 |
pancreatic β cell, HFDG14.5WT, H3K27ac, biol rep2 |
| GSM7743361 |
pancreatic β cell, SDG14.5, H3K27ac, biol rep1 |
| GSM7743362 |
pancreatic β cell, SDG14.5, H3K27ac, biol rep2 |
| GSM7743363 |
pancreatic β cell, G0, H3K27me3, biol rep1 |
| GSM7743364 |
pancreatic β cell, G0, H3K27me3, biol rep2 |
| GSM7743365 |
pancreatic β cell, G14.5, H3K27me3, biol rep1 |
| GSM7743366 |
pancreatic β cell, G14.5, H3K27me3, biol rep2 |
| GSM7743367 |
pancreatic β cell, P7NL, H3K27me3, biol rep1 |
| GSM7743368 |
pancreatic β cell, P7NL, H3K27me3, biol rep2 |
| GSM7743369 |
pancreatic β cell, G0, H3K4me1, biol rep1 |
| GSM7743370 |
pancreatic β cell, G0, H3K4me1, biol rep2 |
| GSM7743371 |
pancreatic β cell, G14.5, H3K4me1, biol rep1 |
| GSM7743372 |
pancreatic β cell, G14.5, H3K4me1, biol rep2 |
| GSM7743373 |
pancreatic β cell, P7NL, H3K4me1, biol rep1 |
| GSM7743374 |
pancreatic β cell, P7NL, H3K4me1, biol rep2 |
| GSM7743375 |
pancreatic β cell, G0, p300, biol rep1 |
| GSM7743376 |
pancreatic β cell, G0, p300, biol rep2 |
| GSM7743377 |
pancreatic β cell, G14.5, p300, biol rep1 |
| GSM7743378 |
pancreatic β cell, G14.5, p300, biol rep2 |
| GSM7743379 |
pancreatic β cell, P7NL, p300, biol rep1 |
| GSM7743380 |
pancreatic β cell, P7NL, p300, biol rep2 |
| GSM7743381 |
pancreatic β cell, G0, STAT3, biol rep1 |
| GSM7743382 |
pancreatic β cell, G0, STAT3, biol rep2 |
| GSM7743383 |
pancreatic β cell, G0, STAT3, rep3 |
| GSM7743384 |
pancreatic β cell, G14.5, STAT3, biol rep1 |
| GSM7743385 |
pancreatic β cell, G14.5, STAT3, biol rep2 |
| GSM7743386 |
pancreatic β cell, G14.5, STAT3, rep3 |
| GSM7743387 |
pancreatic β cell, P7NL, STAT3, biol rep1 |
| GSM7743388 |
pancreatic β cell, P7NL, STAT3, biol rep2 |
| GSM7743389 |
pancreatic β cell, P7NL, STAT3, rep3 |
| GSM7743390 |
pancreatic β cell, human normal serum (NS), H3K27ac |
| GSM7743391 |
pancreatic β cell, human normal serum (NS) + prolactin, H3K27ac |
| GSM7743392 |
pancreatic β cell, human maternal serum (MS), H3K27ac, biol rep1 |
| GSM7743393 |
pancreatic β cell, human maternal serum (MS), H3K27ac, biol rep2 |
| GSM7743394 |
pancreatic β cell, human normal serum (NS), H3K27ac, biol rep1 |
| GSM7743395 |
pancreatic β cell, human normal serum (NS), H3K27ac, biol rep2 |
|
| This SubSeries is part of SuperSeries: |
| GSE241776 |
ACSS2 mediates an epigenetic pathway to regulate maternal Beta-cell adaptation and progression of gestational diabetes |
|
| Relations |
| BioProject |
PRJNA1009853 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE241773_G0_ATAC_rep1.bedgraph.gz |
73.6 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_ATAC_rep2.bedgraph.gz |
57.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_H3K27ac.bed.gz |
294.1 Kb |
(ftp)(http) |
BED |
| GSE241773_G0_H3K27ac_rep1.bedgraph.gz |
164.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_H3K27ac_rep2.bedgraph.gz |
168.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_H3K27me3_rep1.bedgraph.gz |
499.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_H3K27me3_rep2.bedgraph.gz |
492.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_H3K4me1.bed.gz |
458.0 Kb |
(ftp)(http) |
BED |
| GSE241773_G0_H3K4me1_rep1.bedgraph.gz |
100.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_H3K4me1_rep2.bedgraph.gz |
67.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_STAT3.bed.gz |
69.8 Kb |
(ftp)(http) |
BED |
| GSE241773_G0_STAT3_rep1.bedgraph.gz |
32.6 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_STAT3_rep1.nor.bedgraph.gz |
32.6 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_STAT3_rep2.bedgraph.gz |
20.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_STAT3_rep2.nor.bedgraph.gz |
20.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_STAT3_rep3.bedgraph.gz |
18.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_STAT3_rep3.nor.bedgraph.gz |
18.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_p300.bed.gz |
127.3 Kb |
(ftp)(http) |
BED |
| GSE241773_G0_p300_rep1.bedgraph.gz |
28.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G0_p300_rep2.bedgraph.gz |
46.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_ATAC_rep1.bedgraph.gz |
75.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_ATAC_rep2.bedgraph.gz |
75.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_H3K27ac_rep1.bedgraph.gz |
110.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_H3K27ac_rep2.bedgraph.gz |
179.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_H3K27me3_rep1.bedgraph.gz |
264.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_H3K27me3_rep2.bedgraph.gz |
348.7 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_H3K4me1.bed.gz |
490.0 Kb |
(ftp)(http) |
BED |
| GSE241773_G14.5_H3K4me1_rep1.bedgraph.gz |
55.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_H3K4me1_rep2.bedgraph.gz |
118.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_H3k27ac.bed.gz |
282.0 Kb |
(ftp)(http) |
BED |
| GSE241773_G14.5_STAT3.bed.gz |
48.3 Kb |
(ftp)(http) |
BED |
| GSE241773_G14.5_STAT3_rep1.bedgraph.gz |
54.6 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_STAT3_rep1.nor.bedgraph.gz |
55.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_STAT3_rep2.bedgraph.gz |
23.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_STAT3_rep2.nor.bedgraph.gz |
23.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_STAT3_rep3.bedgraph.gz |
59.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_STAT3_rep3.nor.bedgraph.gz |
59.7 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_p300.bed.gz |
179.8 Kb |
(ftp)(http) |
BED |
| GSE241773_G14.5_p300_rep1.bedgraph.gz |
22.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G14.5_p300_rep2.bedgraph.gz |
33.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Acss2KO_H3K27ac.bed.gz |
235.1 Kb |
(ftp)(http) |
BED |
| GSE241773_G18.5Acss2KO_H3K27ac_rep1.bedgraph.gz |
14.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Acss2KO_H3K27ac_rep2.bedgraph.gz |
14.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Acss2KO_H3K27ac_rep3.bedgraph.gz |
21.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Acss2WT_H3K27ac.bed.gz |
297.5 Kb |
(ftp)(http) |
BED |
| GSE241773_G18.5Acss2WT_H3K27ac_rep1.bedgraph.gz |
34.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Acss2WT_H3K27ac_rep2.bedgraph.gz |
38.7 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Acss2WT_H3K27ac_rep3.bedgraph.gz |
12.7 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Stat3KO_H3K27ac.bed.gz |
205.5 Kb |
(ftp)(http) |
BED |
| GSE241773_G18.5Stat3KO_H3K27ac_rep1.bedgraph.gz |
15.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Stat3KO_H3K27ac_rep2.bedgraph.gz |
13.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Stat3KO_H3K27ac_rep3.bedgraph.gz |
15.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Stat3WT_H3K27ac.bed.gz |
246.7 Kb |
(ftp)(http) |
BED |
| GSE241773_G18.5Stat3WT_H3K27ac_rep1.bedgraph.gz |
22.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Stat3WT_H3K27ac_rep2.bedgraph.gz |
36.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_G18.5Stat3WT_H3K27ac_rep3.bedgraph.gz |
33.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG0_ATAC.bed.gz |
255.6 Kb |
(ftp)(http) |
BED |
| GSE241773_HFDG0_ATAC_rep1.bedgraph.gz |
31.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG0_ATAC_rep2.bedgraph.gz |
40.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG0_H3K27ac.bed.gz |
179.5 Kb |
(ftp)(http) |
BED |
| GSE241773_HFDG0_H3K27ac_rep1.bedgraph.gz |
35.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG0_H3K27ac_rep1.nor.bedgraph.gz |
35.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG0_H3K27ac_rep2.bedgraph.gz |
17.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG0_H3K27ac_rep2.nor.bedgraph.gz |
17.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5Acss2KO_H3K27ac.bed.gz |
132.8 Kb |
(ftp)(http) |
BED |
| GSE241773_HFDG14.5KO_H3K27ac_rep1.bedgraph.gz |
11.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5KO_H3K27ac_rep1.nor.bedgraph.gz |
11.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5KO_H3K27ac_rep2.bedgraph.gz |
12.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5KO_H3K27ac_rep2.nor.bedgraph.gz |
12.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5WT_H3K27ac.bed.gz |
168.3 Kb |
(ftp)(http) |
BED |
| GSE241773_HFDG14.5WT_H3K27ac_rep1.bedgraph.gz |
13.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5WT_H3K27ac_rep1.nor.bedgraph.gz |
13.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5WT_H3K27ac_rep2.bedgraph.gz |
16.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5WT_H3K27ac_rep2.nor.bedgraph.gz |
16.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5_ATAC.bed.gz |
505.5 Kb |
(ftp)(http) |
BED |
| GSE241773_HFDG14.5_ATAC_rep1.bedgraph.gz |
82.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_HFDG14.5_ATAC_rep2.bedgraph.gz |
77.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_MS_H3K27ac_rep1.bedgraph.gz |
96.6 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_MS_H3K27ac_rep2.bedgraph.gz |
81.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_NS_H3K27ac_rep1.bedgraph.gz |
97.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_NS_H3K27ac_rep2.bedgraph.gz |
112.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_NS_ProlactinCtrl_H3K27ac.bed.gz |
88.5 Kb |
(ftp)(http) |
BED |
| GSE241773_NS_ProlactinCtrl_H3K27ac.bedgraph.gz |
43.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_NS_Prolactin_H3K27ac.bed.gz |
161.2 Kb |
(ftp)(http) |
BED |
| GSE241773_NS_Prolactin_H3K27ac.bedgraph.gz |
56.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_ATAC.bed.gz |
312.4 Kb |
(ftp)(http) |
BED |
| GSE241773_P7NL_ATAC_rep1.bedgraph.gz |
42.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_ATAC_rep2.bedgraph.gz |
57.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_H3K27ac.bed.gz |
177.6 Kb |
(ftp)(http) |
BED |
| GSE241773_P7NL_H3K27ac_rep1.bedgraph.gz |
238.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_H3K27ac_rep2.bedgraph.gz |
91.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_H3K27me3_rep1.bedgraph.gz |
246.8 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_H3K27me3_rep2.bedgraph.gz |
434.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_H3K4me1.bed.gz |
313.4 Kb |
(ftp)(http) |
BED |
| GSE241773_P7NL_H3K4me1_rep1.bedgraph.gz |
44.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_H3K4me1_rep2.bedgraph.gz |
51.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_STAT3.bed.gz |
100.1 Kb |
(ftp)(http) |
BED |
| GSE241773_P7NL_STAT3_rep1.bedgraph.gz |
23.1 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_STAT3_rep1.nor.bedgraph.gz |
23.0 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_STAT3_rep2.bedgraph.gz |
64.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_STAT3_rep2.nor.bedgraph.gz |
64.6 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_STAT3_rep3.bedgraph.gz |
21.4 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_STAT3_rep3.nor.bedgraph.gz |
21.3 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_p300.bed.gz |
234.9 Kb |
(ftp)(http) |
BED |
| GSE241773_P7NL_p300_rep1.bedgraph.gz |
52.7 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_P7NL_p300_rep2.bedgraph.gz |
82.2 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_SDG0_ATAC.bed.gz |
321.6 Kb |
(ftp)(http) |
BED |
| GSE241773_SDG14.5_ATAC.bed.gz |
420.5 Kb |
(ftp)(http) |
BED |
| GSE241773_SDG14.5_H3K27ac.bed.gz |
241.5 Kb |
(ftp)(http) |
BED |
| GSE241773_SDG14.5_H3K27ac_rep1.bedgraph.gz |
48.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_SDG14.5_H3K27ac_rep1.nor.bedgraph.gz |
48.5 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_SDG14.5_H3K27ac_rep2.bedgraph.gz |
13.9 Mb |
(ftp)(http) |
BEDGRAPH |
| GSE241773_SDG14.5_H3K27ac_rep2.nor.bedgraph.gz |
13.9 Mb |
(ftp)(http) |
BEDGRAPH |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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