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| Status |
Public on Jun 18, 2024 |
| Title |
A single cell altas of mouse embryonic diapause and peri-implantation development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here, we molecularly defined embryonic diapause at single-cell resolution, revealing hidden transcriptional dynamics while seemingly the embryo resides in a state of suspended animation. Alongside, we found that the dormant pluripotent cells are “aware” of their microenvironment which sustains their viability via Yap-mediated mechanotransduction.
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| Overall design |
Approximately 200~250 blastocysts from each developmental stage – E4.5, EDG7.5, EDG9.5 and Reactivated and 50 embryos from E5.5 stage were collected and analyzed using sc-RNA seq.
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| Web link |
https://www.sciencedirect.com/science/article/pii/S1934590924002509?via%3Dihub
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| |
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| Contributor(s) |
Chen R, Jeong H, Fan R, Chen F, Govindasamy N, Stehling M, Adams RH, Bedzhov I |
| Citation(s) |
39047740 |
| |
| Submission date |
Aug 22, 2023 |
| Last update date |
Sep 17, 2024 |
| Contact name |
Hyun-Woo Jeong |
| E-mail(s) |
zionjeong@gmail.com
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| Phone |
+4917631115236
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| Organization name |
Max-Planck-Institute for Molecular Biomedicine
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| Department |
Dept. Tissue Morphogenesis
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| Lab |
Adams
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| Street address |
Roentgenstr.20
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| City |
Muenster |
| State/province |
NRW |
| ZIP/Postal code |
48149 |
| Country |
Germany |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE241463 |
Defining embryo dormancy at single-cell resolution reveals cryptic transcriptional dynamics apace with Yap-mediated mechanotransduction |
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| Relations |
| BioProject |
PRJNA1008213 |
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