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| Status |
Public on Dec 31, 2023 |
| Title |
Regulation of gene expression by GLIS3 during neonatal kidney development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Loss of transcription factor GLIS3 function in humans and mice leads to the development of neonatal polycystic kidney disease (PKD). To investigate how loss of GLIS3 function in kidney affects postnatal kidney development and PKD, we analyzed the gene expression profiles of kidneys from WT and Glis3-null mice at P7, P14, and P28 by RNA-Seq analysis using Glis3 global KO model Glis3-mCherry and kidney specific knockout model Glis3-PAX8Cre.
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| Overall design |
Total kidney RNAs were isolated from WT and Glis3-null mice and gene expression profiles were analyzed by RNA-Seq.
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| Contributor(s) |
Jetten AM, Srivastava C, Kang HS, Collier J, Grimm SA |
| Citation(s) |
39505148 |
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| Submission date |
Aug 04, 2023 |
| Last update date |
Dec 18, 2024 |
| Contact name |
Hong Soon Kang |
| E-mail(s) |
kang1@niehs.nih.gov
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| Phone |
984-287-3921
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| Organization name |
NIH/NIEHS
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| Department |
IIDL
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| Lab |
Cell Biology Group
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| Street address |
111 T.W. Alexander Dr.
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| City |
Research Triangle Park |
| State/province |
NC |
| ZIP/Postal code |
27709 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (59)
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| GSM7680858 |
kidney, PND7, mCherry Glis3 KO, rep4 |
| GSM7680859 |
kidney, PND7, mCherry Glis3 KO, rep5 |
| GSM7680860 |
kidney, PND7, mCherry Glis3 WT, rep1 |
| GSM7680861 |
kidney, PND7, mCherry Glis3 WT, rep2 |
| GSM7680862 |
kidney, PND7, mCherry Glis3 WT, rep3 |
| GSM7680863 |
kidney, PND7, mCherry Glis3 WT, rep4 |
| GSM7680864 |
kidney, PND7, mCherry Glis3 WT, rep5 |
| GSM7680865 |
kidney, PND14, mCherry Glis3 KO, rep1 |
| GSM7680866 |
kidney, PND14, mCherry Glis3 KO, rep2 |
| GSM7680867 |
kidney, PND14, mCherry Glis3 KO, rep3 |
| GSM7680868 |
kidney, PND14, mCherry Glis3 KO, rep4; outlier removed from analysis |
| GSM7680869 |
kidney, PND14, mCherry Glis3 KO, rep5 |
| GSM7680870 |
kidney, PND14, mCherry Glis3 WT, rep1 |
| GSM7680871 |
kidney, PND14, mCherry Glis3 WT, rep2 |
| GSM7680872 |
kidney, PND14, mCherry Glis3 WT, rep3 |
| GSM7680873 |
kidney, PND14, mCherry Glis3 WT, rep4 |
| GSM7680874 |
kidney, PND14, mCherry Glis3 WT, rep5 |
| GSM7680875 |
kidney, PND28, mCherry Glis3 KO, rep1 |
| GSM7680876 |
kidney, PND28, mCherry Glis3 KO, rep2 |
| GSM7680877 |
kidney, PND28, mCherry Glis3 KO, rep3 |
| GSM7680878 |
kidney, PND28, mCherry Glis3 KO, rep4 |
| GSM7680879 |
kidney, PND28, mCherry Glis3 KO, rep5 |
| GSM7680880 |
kidney, PND28, mCherry Glis3 WT, rep1 |
| GSM7680881 |
kidney, PND28, mCherry Glis3 WT, rep2 |
| GSM7680882 |
kidney, PND28, mCherry Glis3 WT, rep3 |
| GSM7680883 |
kidney, PND28, mCherry Glis3 WT, rep4 |
| GSM7680884 |
kidney, PND28, mCherry Glis3 WT, rep5 |
| GSM7680885 |
kidney, PND7, PAX8-cre Glis3 KO, rep1 |
| GSM7680886 |
kidney, PND7, PAX8-cre Glis3 KO, rep2 |
| GSM7680887 |
kidney, PND7, PAX8-cre Glis3 KO, rep3 |
| GSM7680888 |
kidney, PND7, PAX8-cre Glis3 KO, rep4 |
| GSM7680889 |
kidney, PND7, PAX8-cre Glis3 KO, rep5 |
| GSM7680890 |
kidney, PND7, PAX8-cre Glis3 WT, rep1 |
| GSM7680891 |
kidney, PND7, PAX8-cre Glis3 WT, rep2 |
| GSM7680892 |
kidney, PND7, PAX8-cre Glis3 WT, rep3 |
| GSM7680893 |
kidney, PND7, PAX8-cre Glis3 WT, rep4 |
| GSM7680894 |
kidney, PND7, PAX8-cre Glis3 WT, rep5 |
| GSM7680895 |
kidney, PND14, PAX8-cre Glis3 KO, rep1 |
| GSM7680896 |
kidney, PND14, PAX8-cre Glis3 KO, rep2 |
| GSM7680897 |
kidney, PND14, PAX8-cre Glis3 KO, rep3 |
| GSM7680898 |
kidney, PND14, PAX8-cre Glis3 KO, rep4 |
| GSM7680899 |
kidney, PND14, PAX8-cre Glis3 KO, rep5 |
| GSM7680900 |
kidney, PND14, PAX8-cre Glis3 WT, rep1 |
| GSM7680901 |
kidney, PND14, PAX8-cre Glis3 WT, rep2 |
| GSM7680902 |
kidney, PND14, PAX8-cre Glis3 WT, rep3 |
| GSM7680903 |
kidney, PND14, PAX8-cre Glis3 WT, rep4 |
| GSM7680904 |
kidney, PND14, PAX8-cre Glis3 WT, rep5 |
| GSM7680905 |
kidney, PND28, PAX8-cre Glis3 KO, rep1 |
| GSM7680906 |
kidney, PND28, PAX8-cre Glis3 KO, rep2 |
| GSM7680907 |
kidney, PND28, PAX8-cre Glis3 KO, rep3 |
| GSM7680908 |
kidney, PND28, PAX8-cre Glis3 KO, rep4 |
| GSM7680909 |
kidney, PND28, PAX8-cre Glis3 KO, rep5 |
| GSM7680910 |
kidney, PND28, PAX8-cre Glis3 WT, rep1 |
| GSM7680911 |
kidney, PND28, PAX8-cre Glis3 WT, rep3 |
| GSM7680912 |
kidney, PND28, PAX8-cre Glis3 WT, rep4 |
| GSM7680913 |
kidney, PND28, PAX8-cre Glis3 WT, rep5 |
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA1002245 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE240071_RAW.tar |
11.4 Gb |
(http)(custom) |
TAR (of BIGWIG) |
| GSE240071_RNAseq_counts-per-gene.PAX8cre_dataset.txt.gz |
1.9 Mb |
(ftp)(http) |
TXT |
| GSE240071_RNAseq_counts-per-gene.mCherry_dataset.txt.gz |
1.9 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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