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Series GSE23907 Query DataSets for GSE23907
Status Public on Oct 31, 2010
Title Histone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers contribute to the specific gene expression programs that determine cell state and the potential for differentiation into new cell types. While enhancer elements are known to be associated with certain histone modifications, and transcription factors, the relationship of these modifications to gene expression and developmental state has not been clearly defined. Here we interrogate the epigenetic landscape of enhancer elements in embryonic stem cells and several adult tissues in the mouse. We find that histone H3K27ac distinguishes active enhancers from inactive/poised enhancer elements, thus providing clues to current cell state and further developmental potential.
Overall design Gene expression profiling was performed in mouse ES, NPC, liver, and pro-B
Contributor(s) Creyghton MP, Cheng AW, Jaenisch R
Citation(s) 21106759
Submission date Aug 31, 2010
Last update date May 10, 2018
Contact name Menno P Creyghton
Organization name Hubrecht Institute
Lab Creyghton
Street address Uppsalalaan 8
City Utrecht
ZIP/Postal code 3584 CT
Country Netherlands
Platforms (1)
GPL4134 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)
Samples (8)
GSM589518 V6.5 ES cell (Replicate 1)
GSM589519 V6.5 ES cell (Replicate 2)
GSM589520 Neural Progenitor Cell (Replicate 1)
This SubSeries is part of SuperSeries:
GSE24165 Histone H3K27ac separates active from poised enhancers and predicts developmental state
BioProject PRJNA133189

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23907_RAW.tar 70.3 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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